CAJ | 학술논문

目的：探讨冠心病合并2型糖尿病患者血清中D-二聚体水平与N末端脑钠肽前体（ NT-porB-NP）的相关性。方法选取50例冠心病合并2型糖尿病患者作为研究组，并选取同期体检健康者30例为健康对照组。检测两组血清中 D-二聚体水平和 NT-porBNP 的含量水平，并经统计学分析两者的相关性。结果研究组血清中D-二聚体、NT-porBNP水平分别为（2．43±0．58）mg/L、（1487．8±201．5）pg/L，均高于健康对照组的（0．26±0．13）mg/L、（83．3±21．4）pg/L（t＝21．34、32．12，均P＜0．05）。 D-二聚体水平和NT-porBNP的含量水平呈明显正相关（r＝0.564，P＜0．05）。结论冠心病合并2型糖尿病患者血清中D-二聚体和NT-proBNP的含量水平密切相关，且高水平表达。
목적：탐토관심병합병2형당뇨병환자혈청중D-이취체수평여N말단뇌납태전체（ NT-porB-NP）적상관성。방법선취50례관심병합병2형당뇨병환자작위연구조，병선취동기체검건강자30례위건강대조조。검측량조혈청중 D-이취체수평화 NT-porBNP 적함량수평，병경통계학분석량자적상관성。결과연구조혈청중D-이취체、NT-porBNP수평분별위（2．43±0．58）mg/L、（1487．8±201．5）pg/L，균고우건강대조조적（0．26±0．13）mg/L、（83．3±21．4）pg/L（t＝21．34、32．12，균P＜0．05）。 D-이취체수평화NT-porBNP적함량수평정명현정상관（r＝0.564，P＜0．05）。결론관심병합병2형당뇨병환자혈청중D-이취체화NT-proBNP적함량수평밀절상관，차고수평표체。
Objective To explore the correlation between N-terminal pro-brain natriuretic peptide ( NT-porB-NP) and D-dimer in coronary artery disease patients with type 2 diabetes .Methods 50 coronary heart disease patients with type 2 diabetes were selected as the study group ,and 30 healthy subjects at the same period were select-ed as the healthy control group .The serum levels of NT-porBNP and D-dimer were detected in two groups ,and the cor-relation between NT-porBNP and D-dimer was analyzed .Results The serum D-dimer and NT-porBNP levels in the study group were significantly higher than those in the control group [(2.43 ±0.58)mg/L vs (0.26 ±0.13)mg/L, (1 487.8 ±201.5)pg/L vs (83.3 ±21.4)pg/L](t=21.34,32.12,all P<0.05).The D-dimer level was positively correlated with the NT-porBNP level (r=0.564,P<0.05).Conclusion In coronary heart disease patients with type 2 diabetes ,the serum levels of D-dimer and NT-proBNP are high and closely related .