CAJ | 학술논문

目的：探讨血清缺血修饰白蛋白（ IMA）检测对急性冠脉综合征（ ACS）的早期诊断意义。方法采用白蛋白钴结合试验检测97例疑似ACS 患者（观察组）3 h内血清标本，间接测定白蛋白与钴离子的结合能力（ ACB）来测定IMA，采用免疫抑制法检测肌酸激酶、肌酸激酶同功酶，化学发光法检测肌红蛋白、肌钙蛋白Ⅰ，观察它们的变化水平，同时对59例健康体检者（对照组）检测IMA水平。结果观察组ACB （53.55±8．23）U/mL，明显低于对照组的（78．00±6．35） U/mL（ t＝34．51，P＜0．01）；观察组IMA 阳性率84.8％，均明显高于其他四种心肌标志物（肌酸激酶、肌酸激酶同功酶、肌红蛋白、肌钙蛋白Ⅰ）（χ2＝17．34、15.21、13．34、13．38，均P＜0．01）。结论对ACS患者进行IMA检测，可做到早期诊断，值得临床推广应用。
목적：탐토혈청결혈수식백단백（ IMA）검측대급성관맥종합정（ ACS）적조기진단의의。방법채용백단백고결합시험검측97례의사ACS 환자（관찰조）3 h내혈청표본，간접측정백단백여고리자적결합능력（ ACB）래측정IMA，채용면역억제법검측기산격매、기산격매동공매，화학발광법검측기홍단백、기개단백Ⅰ，관찰타문적변화수평，동시대59례건강체검자（대조조）검측IMA수평。결과관찰조ACB （53.55±8．23）U/mL，명현저우대조조적（78．00±6．35） U/mL（ t＝34．51，P＜0．01）；관찰조IMA 양성솔84.8％，균명현고우기타사충심기표지물（기산격매、기산격매동공매、기홍단백、기개단백Ⅰ）（χ2＝17．34、15.21、13．34、13．38，균P＜0．01）。결론대ACS환자진행IMA검측，가주도조기진단，치득림상추엄응용。
Objective To expore the early diagnostic value of the detection of serum ischemia modified albu-min( IMA) for acute coronary syndrome ( ACS) .Methods Albumin cobalt binding assay was used to detect the ser-um samples in 97 cases of suspected ACS ( the observation group ) within three hours ,and IMA was determined by in-direct determination of the binding capacity of albumin and cobalt ions .Immunosuppressive assay was used to detect CK and CKMB.The levels of MYO and troponin Ⅰwere observed by chemiluminescence assay .Meanwhile,the IMA level in 59 healthy subjects ( the control group ) was detected.Results The ACB of the observation group was (53.55 ±8.23)U/mL,which was lower than (78.00 ±6.35)U/mL of the control group(t=34.51,P<0.01).The positive rate of IMA in the observation group was 84.8%,which was significantly higher than the positive rate of CK , CK-MB,MYO,CTnI(χ2 =17.34,15.21,13.34,13.38,all P<0.01).Conclusion IMA detection in patients with ACS can help early diagnosis ,which is worthy of clinical popularization and application .