CAJ | 학술논문

目的：探讨孟鲁司特在支气管哮喘中的疗效及预防效果。方法选取2010年1月至2012年8月于本院进行治疗的94例支气管哮喘患儿为研究对象，将其随机分为对照组（常规治疗组）和观察组（常规治疗联合孟鲁司特组）各47例，比较两组患者的治疗总有效率和治疗前、治疗后6周、12周血清总IgE、IL-6、CRP及IL-1水平。结果观察组轻度、中度和重度患者治疗总有效率均高于对照组，而治疗后6周、12周血清总IgE、IL-6、CRP及IL-1水平均低于对照组，其差异均具有统计学意义(P<0.05)。结论孟鲁司特治疗支气管哮喘疗效较佳，其可通过调整哮喘相关因子来达到预防的目的。
목적：탐토맹로사특재지기관효천중적료효급예방효과。방법선취2010년1월지2012년8월우본원진행치료적94례지기관효천환인위연구대상，장기수궤분위대조조（상규치료조）화관찰조（상규치료연합맹로사특조）각47례，비교량조환자적치료총유효솔화치료전、치료후6주、12주혈청총IgE、IL-6、CRP급IL-1수평。결과관찰조경도、중도화중도환자치료총유효솔균고우대조조，이치료후6주、12주혈청총IgE、IL-6、CRP급IL-1수평균저우대조조，기차이균구유통계학의의(P<0.05)。결론맹로사특치료지기관효천료효교가，기가통과조정효천상관인자래체도예방적목적。
Objective To study the therapeutic and preventive effect of montelukast on bronchial asthma. Methods 94 patients with bronchial asthma in our hospital from January 2010 to August 2012 were selected as re-search objects, and were randomly divided into control group (routine treatment group, n=47) and observation group (routine treatment combined with montelukast group, n=47). Then the total effective rate and serum total IgE, IL-6, CRP and IL-1 were compared before and after the treatment at the sixth and twelfth week of two groups. Results The effective rares of observation group with mild,moderate and severe were all higher than those of control group,, and serum total IgE, IL-6, CRP and IL-1 after the treatment at the sixth and twelfth week were all lower than those of con-trol group,and serum IL-10 were higher than that of control group, all the P<0.05. Conclusion The therapeutic ef-fect of montelukast in patients with bronchial asthma is better, and it can effectively prevent the disease by adjusting the asthma related factors.