CAJ | 학술논문

目的：观察自体外周血干细胞移植治疗乙型肝硬化的近期疗效。方法选择50例乙型肝炎肝硬化失代偿期的患者，分为治疗组（26例）和对照组（24例）。对照组给予维生素、复合辅酶、异甘草酸镁等一般综合治疗及抗乙型肝炎病毒治疗，治疗组在对照组治疗基础上给予自体外周血干细胞移植治疗。治疗后定期复查丙氨酸氨基转移酶（ALT）、天门冬氨酸氨基转移酶（AST）、清蛋白（ALB）、总胆红素（TBIL）、凝血酶原活动度（PTA）水平变化及Child-Pugh评分变化，观察患者临床症状变化与不良反应。结果在治疗后第4周，治疗组较对照组患者血清ALT、AST、ALB、PTA均有明显改善（P＜0．05），TBIL改善无显著差异。4周后治疗组各临床症状较对照组明显改善，乏力改善20例（76．9％）、食欲改善16例（61．5％）、腹水减少或完全消失22例（84．6％），未发生严重并发症。结论自体外周血干细胞移植治疗乙型肝炎肝硬化近期安全有效，患者肝功能改善明显。
목적：관찰자체외주혈간세포이식치료을형간경화적근기료효。방법선택50례을형간염간경화실대상기적환자，분위치료조（26례）화대조조（24례）。대조조급여유생소、복합보매、이감초산미등일반종합치료급항을형간염병독치료，치료조재대조조치료기출상급여자체외주혈간세포이식치료。치료후정기복사병안산안기전이매（ALT）、천문동안산안기전이매（AST）、청단백（ALB）、총담홍소（TBIL）、응혈매원활동도（PTA）수평변화급Child-Pugh평분변화，관찰환자림상증상변화여불량반응。결과재치료후제4주，치료조교대조조환자혈청ALT、AST、ALB、PTA균유명현개선（P＜0．05），TBIL개선무현저차이。4주후치료조각림상증상교대조조명현개선，핍력개선20례（76．9％）、식욕개선16례（61．5％）、복수감소혹완전소실22례（84．6％），미발생엄중병발증。결론자체외주혈간세포이식치료을형간염간경화근기안전유효，환자간공능개선명현。
Objective To observe the curative effect of autologous peripheral blood stem cell transplantation in the treatment of hepatitis B cirrhosis .Methods A total of 50 patients with hepatitis B virus related decompensated cirrhosis ,including 26 cases receiving autologous peripheral blood stem cell transplantation treatment and general treatment (treatment group) ,and 24 receiving general treatment (control group) .After treatment ,alanine amin-otransferase (ALT ) ,aspartate aminotransferase (AST ) ,albumin (ALB) ,total bilirubin (TBIL) ,prothrombin activity (PTA) level and Child-Pugh score were re -detected ,and adverse reactions and clinical symptoms were observed .Re-sults At the fourth week after treatment ,levels of ALT ,AST ,ALB and PTA were significantly improved ,compared with control group (P<0 .05) ,but improvement of TBIL were without significant difference .After 4 weeks of treat-ment ,clinical symptoms in treatment gorup were significantly improved than control group ,including fatigue im-proved in 20 cases (76 .9% ) ,appetite improved in 16 cases (61 .5% ) ,ascites decreased or disappeared completely in 22 cases (84 .6% ) ,and no serious complication was found .Conclusion Autologous peripheral blood stem cell trans-plantation for treatment of hepatitis B cirrhosis could be with recent safety and effectiveness ,and could improve the liver function of patients .