CAJ | 학술논문

目的：探讨2型糖尿病患者血清CA19-9水平变化及其影响因素。方法测定60例健康体检者（健康对照组）和120例糖尿病患者（分血糖控制良好组与血糖控制不良组）血清CA19-9水平，比较组间差异，并对糖尿病患者血清CA19-9水平的影响因素进行相关性分析。结果2型糖尿病组血清CA19-9水平为（14．80±12．45） U/mL ，明显高于健康对照组的（6．34±3．55）U/mL ，差异有统计学意义（P＜0．01）；血糖控制不良组血清CA19-9水平（20．85±14．88）U/mL明显高于血糖控制良好组的（8．76 ± 4．15）U/mL 和健康对照组，差异有统计学意义（P＜0．01）；血糖控制良好组血清 CA19-9水平（8．76 ± 4．15）U/mL 较健康对照组高，差异有统计学意义（P＜0．01）。CA19-9水平与糖化血红蛋白呈正相关（r＝0．3078，P＜0．05）。结论2型糖尿病患者血清CA19-9水平高于健康者，且与糖化血红蛋白水平相关。
목적：탐토2형당뇨병환자혈청CA19-9수평변화급기영향인소。방법측정60례건강체검자（건강대조조）화120례당뇨병환자（분혈당공제량호조여혈당공제불량조）혈청CA19-9수평，비교조간차이，병대당뇨병환자혈청CA19-9수평적영향인소진행상관성분석。결과2형당뇨병조혈청CA19-9수평위（14．80±12．45） U/mL ，명현고우건강대조조적（6．34±3．55）U/mL ，차이유통계학의의（P＜0．01）；혈당공제불량조혈청CA19-9수평（20．85±14．88）U/mL명현고우혈당공제량호조적（8．76 ± 4．15）U/mL 화건강대조조，차이유통계학의의（P＜0．01）；혈당공제량호조혈청 CA19-9수평（8．76 ± 4．15）U/mL 교건강대조조고，차이유통계학의의（P＜0．01）。CA19-9수평여당화혈홍단백정정상관（r＝0．3078，P＜0．05）。결론2형당뇨병환자혈청CA19-9수평고우건강자，차여당화혈홍단백수평상관。
Objective To investigate serum level of CA19-9 in patients with type 2 diabetes mellitus and relat-ed influencing factors .Methods Serum levels of CA19-9 were detected and compared between 60 healthy subjects (control group) and 120 patients with diabetes mellitus ,who were divided into good glycemic control group and poor glycemic control group ,and influencing factors of serum level of CA19-9 in patients with diabetes mellitus were ana-lyzed .Results Serum levels of CA19-9 in type 2 diabetic group was significantly higher than control group (P<0 .01) ,serum levels of CA19-9 in poor blood glucose control was significantly higher than good glycemic control group and control group (P< 0 .01) ,and serum levels of CA19-9 of good glycemic control group was higher than control group (P<0 .01) .Serum level of CA19-9 in patient with diabetes mellitus was positively correlated with gly-cosylated hemoglobin level (r=0 .307 8 ,P<0 .05) .Conclusion Serum level of CA19-9 in patients with type 2 diabe-tes mellitus could be higher than healthy subjects ,and might be associated with .glycosylated hemoglobin level .