中国肿瘤临床
中國腫瘤臨床
중국종류림상
CHINESE JOURNAL OF CLINICAL ONCOLOGY
2014年
19期
1221-1224
,共4页
JAK激酶%信号传导与转录激活因子3%AG490%淋巴瘤%肿瘤治疗
JAK激酶%信號傳導與轉錄激活因子3%AG490%淋巴瘤%腫瘤治療
JAK격매%신호전도여전록격활인자3%AG490%림파류%종류치료
Janus kinase%signal transducers and activators of transcription 3%AG490%lymphoma%cancer therapy
JAK/STAT是多种细胞因子和生长因子信号转导的重要途径，参与细胞增殖、分化以及免疫调节等多个过程，在肿瘤中的持续性激活可促进肿瘤的发生发展。目前研究发现在淋巴瘤中有STAT3异常表达和活化，其活化与肿瘤生长、侵袭及转移有关。AG490是JAK2抑制剂，可有效地抑制其下游的STAT的活化，阻断JAK/STAT信号转导通路。既往研究证实AG490能抑制淋巴瘤细胞的增殖，促进其凋亡，可提高某些化疗药物的敏感性。本文就JAK/STAT通路及其阻断剂AG490在淋巴瘤中的研究进展作一综述。
JAK/STAT是多種細胞因子和生長因子信號轉導的重要途徑，參與細胞增殖、分化以及免疫調節等多箇過程，在腫瘤中的持續性激活可促進腫瘤的髮生髮展。目前研究髮現在淋巴瘤中有STAT3異常錶達和活化，其活化與腫瘤生長、侵襲及轉移有關。AG490是JAK2抑製劑，可有效地抑製其下遊的STAT的活化，阻斷JAK/STAT信號轉導通路。既往研究證實AG490能抑製淋巴瘤細胞的增殖，促進其凋亡，可提高某些化療藥物的敏感性。本文就JAK/STAT通路及其阻斷劑AG490在淋巴瘤中的研究進展作一綜述。
JAK/STAT시다충세포인자화생장인자신호전도적중요도경，삼여세포증식、분화이급면역조절등다개과정，재종류중적지속성격활가촉진종류적발생발전。목전연구발현재림파류중유STAT3이상표체화활화，기활화여종류생장、침습급전이유관。AG490시JAK2억제제，가유효지억제기하유적STAT적활화，조단JAK/STAT신호전도통로。기왕연구증실AG490능억제림파류세포적증식，촉진기조망，가제고모사화료약물적민감성。본문취JAK/STAT통로급기조단제AG490재림파류중적연구진전작일종술。
JAK/STAT includes many types of cell factors. Growth factor signal transduction is an important pathway and widely participates in cell multiplication, differentiation, and immunity adjustment. Aberrant-activated JAK/STAT signaling pathway is in-volved in carcinogenesis. Recent studies demonstrated that abnormal expression and activation of STAT3 were found in lymphoma. Constitutive activation of STAT3 promotes development, invasion, and metastasis of cancer. AG490, a JAK2 inhibitor, can block the JAK/STAT3 signal pathway and reduce the pathway's downstream STAT3 expression. Several studies showed that AG490 can inhibit cell proliferation and promote apoptosis in lymphoma. AG490 combined with chemotherapy drugs could improve sensitivity. In our study, we reviewed the potential role of JAK/STAT signaling pathway and the blocker AG490 in lymphoma.
