CAJ | 학술논문

目的：研究p-p38和SIAH2蛋白在乳腺浸润性导管癌组织中的表达及与临床病理特征的关系。方法采用免疫组织化学方法检测80例乳腺浸润性导管癌组织标本中p-p38和SIAH2的表达与临床病理因素的关系并分析两者相关性；检测10例癌旁组织中p-p38和SIAH2的表达。结果乳腺浸润性导管癌组织中p-p38及SIAH2的阳性表达率分别为57.5%和60.0%， p-p38和SIAH2表达存在正相关（r=0.330，P＜0.05）。癌旁组织中两种蛋白仅有少量点状表达。p-p38蛋白表达与肿瘤临床分期和淋巴结转移密切相关，SIAH2蛋白表达与肿瘤的组织学分级、临床分期和淋巴结转移密切相关，两种蛋白表达与肿瘤大小、患者年龄无显著相关性。结论p-p38和SIAH2过表达在乳腺癌的发展及浸润转移中具有重要的作用。
목적：연구p-p38화SIAH2단백재유선침윤성도관암조직중적표체급여림상병리특정적관계。방법채용면역조직화학방법검측80례유선침윤성도관암조직표본중p-p38화SIAH2적표체여림상병리인소적관계병분석량자상관성；검측10례암방조직중p-p38화SIAH2적표체。결과유선침윤성도관암조직중p-p38급SIAH2적양성표체솔분별위57.5%화60.0%， p-p38화SIAH2표체존재정상관（r=0.330，P＜0.05）。암방조직중량충단백부유소량점상표체。p-p38단백표체여종류림상분기화림파결전이밀절상관，SIAH2단백표체여종류적조직학분급、림상분기화림파결전이밀절상관，량충단백표체여종류대소、환자년령무현저상관성。결론p-p38화SIAH2과표체재유선암적발전급침윤전이중구유중요적작용。
Objective To investigate the expressions of p-p38 and SIAH2 and their relationship with the clinicopathological factors in breast invasive ductal carcinoma. Methods The expressions of p-p38 and SIAH2 were determined by immunohistochemical staining in 80 cases of breast invasive ductal carcinoma and 10 cases of adjacent normal breast tissues, and relationship between the expressions of p-p38 and SIAH2 and the clinical pathological features was analyzed. Results The positive expression rates of p-p38 and SIAH2 in breast invasive ductal carcinoma were 57.5%and 60.0%, respectively. There was a close relationship between p-p38 and SIAH2 expressions. There was occasional nuclear positivity in the adjacent normal breast tissues. The expression of p-p38 was correlated with TNM stage and lymph node metastasis. The expression of SIAH2 was correlated with histological grade, TNM stage and lymph node metastasis, but no relationship was found between their expressions and the patient's age or tumor size. Conclusion The over expressions of p-p38 and SIAH2 play an important role in the development, invasion, and metastasis of breast cancer.