CAJ | 학술논문

目的：确定血浆D-二聚体诊断早期弥散性血管内凝血（DIC）的最佳临界值。方法收集易引发DIC的疾病患者200例，应用免疫比浊法测定D-二聚体含量，建立受试者工作特征（ROC）曲线，确定针对DIC诊断的最佳临界值。结果确定D-二聚体诊断DIC患者的最佳临界值为4.5，其敏感性为61.5%，特异性为78.3%，阳性预测值为40.7%，阴性预测值为89.4%，曲线下面积为0.702。结论只有合理确定D-二聚体诊断DIC患者的最佳临界值，才能有效保证检测结果的科学性及适用性，为临床诊断提供有效帮助。
목적：학정혈장D-이취체진단조기미산성혈관내응혈（DIC）적최가림계치。방법수집역인발DIC적질병환자200례，응용면역비탁법측정D-이취체함량，건립수시자공작특정（ROC）곡선，학정침대DIC진단적최가림계치。결과학정D-이취체진단DIC환자적최가림계치위4.5，기민감성위61.5%，특이성위78.3%，양성예측치위40.7%，음성예측치위89.4%，곡선하면적위0.702。결론지유합리학정D-이취체진단DIC환자적최가림계치，재능유효보증검측결과적과학성급괄용성，위림상진단제공유효방조。
Objective To determine the optimal critical value of plasma D-dimer in the diagnosis of previously disseminated intravascular coagulation (DIC). Methods Samples from 200 patients with different diseases which easily lead to DIC were collected. D-dimer test was done by immunonephelometry method. Receiver operating characteristic (ROC) curve was applied to determine the optimal critical value of plasma D-dimer for the diagnosis of DIC. Results The optimal critical value of D-dimer for diagnosis of DIC was 4.5. Sensitivity, specificity, positive and negative predictive values were 61.5%, 78.3%, 40.7%and 89.4%respectively. The area under the ROC curve was 0.702 (confidence interval 0.599~0.805). Conclusion The optimal critical value of plasma D-dimer in the diagnosis of DIC can provide the effective help for clinical diagnosis and ensure the results to be scientific and suitable for clinical application.