CAJ | 학술논문

目的：系统评价康艾注射液联合顺铂治疗恶性胸腔积液的疗效和安全性。方法：采用循证医学系统评价方法，计算机检索收集康艾注射液联合顺铂治疗恶性胸腔积液的随机对照试验（RCTs），采用RevMan 5.0软件进行Meta分析。结果：共纳入9篇随机对照研究，共550例病例。Meta分析结果显示：与单纯顺铂治疗恶性胸腔积液比较，联合康艾注射液明显提高恶性胸腔积液治疗效果，改善患者的生活质量，降低骨髓抑制和消化道毒副反应的发生率。结论：康艾注射液联合顺铂能提高恶性胸腔积液患者的治疗效果，改善生活质量，并降低顺铂化疗的毒副作用，值得临床借鉴。
목적：계통평개강애주사액연합순박치료악성흉강적액적료효화안전성。방법：채용순증의학계통평개방법，계산궤검색수집강애주사액연합순박치료악성흉강적액적수궤대조시험（RCTs），채용RevMan 5.0연건진행Meta분석。결과：공납입9편수궤대조연구，공550례병례。Meta분석결과현시：여단순순박치료악성흉강적액비교，연합강애주사액명현제고악성흉강적액치료효과，개선환자적생활질량，강저골수억제화소화도독부반응적발생솔。결론：강애주사액연합순박능제고악성흉강적액환자적치료효과，개선생활질량，병강저순박화료적독부작용，치득림상차감。
Objective To assess the clinical efficacy and safety of Kang’ai injection plus Cisplatin for malignant pleural effusion (MPE).Methods A comprehensive search strategy was designed to identify all randomized controlled trials (RCTs)comparing Kang’ ai injection plus Cisplatin chemotherapy with Cisplatin chemotherapy alone MPE by searching database.RevMan 5.0 software was used for statistical analysis.Results Totally 9 RCTs involving 550 patients were included.The Meta-analysis showed that compared with the application of Cisplatin therapy only,the Cisplatin therapy combination with Kang’ai injection can enhance the curative efficacy, improve the quality of life and reduce the suppression of bone marrow and the gastrointestinal reactions.Conclusion The current evi-dence indicates that Kang’ai injection combined with Cisplatin can enhance the therapeutic effect on MPE patients,improve the quali-ty of life and reduce adverse effect of application of Cisplatin therapy only,and thus it is worth referring in clinic.