CAJ | 학술논문

骨肉瘤是临床最常见的骨恶性肿瘤。骨肉瘤病理确诊后需要即刻进行放化治疗，截肢手术则作为传统切除肿瘤组织的重要方法，该方式对病情起到了较好的控制效果，但对患者的身心伤害较大，严重影响术后生存质量。随着骨肉瘤发病机制的深入研究，针对该病的治疗也取得了较大的进展，保肢治疗成为当前主要治疗方式，具体方法包括手术联合化疗、分子靶向治疗、免疫治疗和基因治疗等，上述方案改善了部分骨肉瘤的治疗效果，减少术后痛苦，提高术后生存率，具有广泛的应用前景。本文对近10年有关该病的治疗进展进行了总结，现将其综述如下。
골육류시림상최상견적골악성종류。골육류병리학진후수요즉각진행방화치료，절지수술칙작위전통절제종류조직적중요방법，해방식대병정기도료교호적공제효과，단대환자적신심상해교대，엄중영향술후생존질량。수착골육류발병궤제적심입연구，침대해병적치료야취득료교대적진전，보지치료성위당전주요치료방식，구체방법포괄수술연합화료、분자파향치료、면역치료화기인치료등，상술방안개선료부분골육류적치료효과，감소술후통고，제고술후생존솔，구유엄범적응용전경。본문대근10년유관해병적치료진전진행료총결，현장기종술여하。
Osteosarcoma is the most common clinical bone malignant tumor.After the pathological diagnosis of osteosarcoma, it is requiremnt for patients to receive chemoradiotherapy treatment. Amputation is a traditional method to remove the tumor tissue, which can play a good control effect for the state of an illness, but do harm to physical and psychological to seriously affect the quality of life after surgery. With the in-depth study of the mechanism of osteosarcoma, the treatment of osteosarcoma has made great progress. Limb salvage surgery is currently the main treatment of the disease, including surgery combined with chemotherapy, molecular targeted therapy, immunotherapy, gene therapy and so on. The programs will improve efficacy of some patients with osteosarcoma, whch reduce postoperative pain and improve survival rates, with a wide range of applications. In this paper, the progress of the past 10 years about the treatment of osteosarcoma are summarized. Now they all were reviewed as follows.