中国医药科学
中國醫藥科學
중국의약과학
CHINA MEDICINE AND PHARMACY
2014年
6期
24-26
,共3页
盐酸贝那普利%硝苯地平控释片%不同给药时间%降压疗效
鹽痠貝那普利%硝苯地平控釋片%不同給藥時間%降壓療效
염산패나보리%초분지평공석편%불동급약시간%강압료효
Benazepril hydrochloride%Nifedipine controlled release tablets%Different administration time%Depressurization efficacy
目的：探讨盐酸贝那普利联合硝苯地平控释片不同给药时间的降压疗效。方法选取2011年3月～2013年3月我院进行治疗的高血压患者115例，按照随机数字分为A、B、C三组。结果三组加服比索洛尔5mg的比率比较，差异不显著（P＞0.05）。各组的24hSBP、24hDBP、24hMABP、dSBP、dDBP、dMABP、nSBP、nDBP、nMABP与治疗前血压比较,均显著下降，差异显著（P＜0.05）。三组血压下降值比较，A组与C组间nSBP、nDBP、nMABP比较差异显著（P＜0.05）；B组与C组间nDBP、nDBP、nMABP比较差异显著（P＜0.05）。平滑指数比较，A组与C组nSBP、nDBP、nMABP差异显著（P＜0.05），B组与C组nSBP、nDBP、nMABP比较差异显著（P＜0.05）。结论依那普利与硝苯地平联合用药能更好地控制老年患者的血压，降压效果十分优越，具有极高的临床应用价值。
目的：探討鹽痠貝那普利聯閤硝苯地平控釋片不同給藥時間的降壓療效。方法選取2011年3月～2013年3月我院進行治療的高血壓患者115例，按照隨機數字分為A、B、C三組。結果三組加服比索洛爾5mg的比率比較，差異不顯著（P＞0.05）。各組的24hSBP、24hDBP、24hMABP、dSBP、dDBP、dMABP、nSBP、nDBP、nMABP與治療前血壓比較,均顯著下降，差異顯著（P＜0.05）。三組血壓下降值比較，A組與C組間nSBP、nDBP、nMABP比較差異顯著（P＜0.05）；B組與C組間nDBP、nDBP、nMABP比較差異顯著（P＜0.05）。平滑指數比較，A組與C組nSBP、nDBP、nMABP差異顯著（P＜0.05），B組與C組nSBP、nDBP、nMABP比較差異顯著（P＜0.05）。結論依那普利與硝苯地平聯閤用藥能更好地控製老年患者的血壓，降壓效果十分優越，具有極高的臨床應用價值。
목적：탐토염산패나보리연합초분지평공석편불동급약시간적강압료효。방법선취2011년3월～2013년3월아원진행치료적고혈압환자115례，안조수궤수자분위A、B、C삼조。결과삼조가복비색락이5mg적비솔비교，차이불현저（P＞0.05）。각조적24hSBP、24hDBP、24hMABP、dSBP、dDBP、dMABP、nSBP、nDBP、nMABP여치료전혈압비교,균현저하강，차이현저（P＜0.05）。삼조혈압하강치비교，A조여C조간nSBP、nDBP、nMABP비교차이현저（P＜0.05）；B조여C조간nDBP、nDBP、nMABP비교차이현저（P＜0.05）。평활지수비교，A조여C조nSBP、nDBP、nMABP차이현저（P＜0.05），B조여C조nSBP、nDBP、nMABP비교차이현저（P＜0.05）。결론의나보리여초분지평연합용약능경호지공제노년환자적혈압，강압효과십분우월，구유겁고적림상응용개치。
Objective To investigate the depressurization efficacy of benazepril hydrochloride combined with nifedipine controlled release tablets administered at different time. Methods 115 patients with hypertension treated in our hospital from March 2011 to March 2013 were selected and divided into group A, group B and group C according to the random number. Results The three groups were not significantly different in the ratio of additional administration of visoprolol 5mg, with no significant difference(P>0.05). The 24hSBP, 24hDBP, 24hMABP, dSBP, dDBP, dMABP, nSBP, nDBP and nMABP of each group after treatment reduced significantly compared to those before treatment, with significant differences(P<0.05). In terms of the drop-out value of blood pressure, group A and group C were significantly different in nSBP, nDBP and nMABP(P<0.05);group B and group C were significantly different in nDBP, nDBP and nMABP(P < 0.05). In terms of smoothness index, group A and group C were significantly different in nSBP, nDBP and nMABP(P < 0.05); group B and group C were significantly different in nSBP, nDBP and nMABP(P < 0.05). Conclusion Benazepril hydrochloride combined with nifedipine controlled release tablets can better control the elder patients' blood pressure, has excellent depressurization effect and is of quite high clinical application value.
