CAJ | 학술논문

目的：探讨JAM-1在不同肌层浸润深度的子宫内膜癌组织中的表达及意义。方法73例子宫内膜癌患者，其中癌细胞无肌层浸润18例，浅层浸润38例，深层浸润17例，采用免疫组化法检测JAM-1在无、浅、深三组浸润深度的表达情况。结果 JAM-1表达在子宫内膜癌癌细胞、腺细胞的胞膜及胞浆，随肌层浸润程度的增加JAM-1的表达显著减弱，差异有统计学意义（P＜0.05）。结论子宫内膜癌JAM-1的表达与癌细胞的浸润程度呈反比，提示JAM-1可能与子宫内膜癌的浸润、侵袭相关。
목적：탐토JAM-1재불동기층침윤심도적자궁내막암조직중적표체급의의。방법73례자궁내막암환자，기중암세포무기층침윤18례，천층침윤38례，심층침윤17례，채용면역조화법검측JAM-1재무、천、심삼조침윤심도적표체정황。결과 JAM-1표체재자궁내막암암세포、선세포적포막급포장，수기층침윤정도적증가JAM-1적표체현저감약，차이유통계학의의（P＜0.05）。결론자궁내막암JAM-1적표체여암세포적침윤정도정반비，제시JAM-1가능여자궁내막암적침윤、침습상관。
Objective To investigate the expression and significance of JAM-1 in the endometrial carcinoma tissues with different myometrial invasion depth. Methods Seventy-three patients with endometrial carcinoma were selected, of which 18 patients were without myometrial invasion, 28 patients had superficial invasion and 17 patients had deep invasion. The immunohistochemistry was used to detect the expression situation of JAM-1 in the three groups with no superficial and deep invasion. Results JAM-1 expressed in the cancer cells of endometrial carcinoma and cell membrane and cytoplasm of glandular cells. As the depth of myometrial invasion increased, the expression of JAM-1 weakened significantly, with statistically significant differences(P < 0.05). Conclusion In endometrial carcinoma, the expression of JAM-1 and invasion depth of cancer cells are negatively correlated, suggesting that JAM-1 may be associated with the invasion of endometrial carcinoma.