中国综合临床
中國綜閤臨床
중국종합림상
CLINICAL MEDICINE OF CHINA
2014年
9期
901-903
,共3页
新生儿先天性心脏病%心力衰竭%心脏缺损%内皮素1%心房利钠肽
新生兒先天性心髒病%心力衰竭%心髒缺損%內皮素1%心房利鈉肽
신생인선천성심장병%심력쇠갈%심장결손%내피소1%심방리납태
Newborns congenital heart disease%Heart failure%Heart defects%Endothelin 1%Atrial natriuretic peptide
目的 探讨新生儿先天性心脏病患儿是否存在内皮素1 (ET-1)和心房利钠肽(ANP)的明显激活及其临床意义.方法 选取100例新生儿先天性心脏病患儿(按心功能分级标准将患者分成几个亚组:Ⅰ级组30例、Ⅱ级组40例、Ⅲ-Ⅳ级组30例),并选取年龄、性别与之相匹配的正常体检新生儿30名作为对照组.检测其ET-1、ANP浓度.结果 新生儿先天性心脏病Ⅲ-Ⅳ级组患儿血循环中的ET-1为(132.35±5.26) ng/L、ANP为(9.25±2.37) pmol/L,与对照组[ET-1(53.62±3.81) ng/L、ANP(1.15±0.09) pmol/L]比较明显增高(P＜0.01).3个亚组随着疾病严重程度的加重,ET-1、ANP的激活就越明显,ET-1与心功能分级呈明显正相关(r=0.35;P ＜0.01);ANP与心功能分级呈明显正相关(r =0.72,P＜0.01).结论 新生儿先天性心脏病患儿的ET-1、ANP明显激活,并具有慢性心力衰竭的特征,其与疾病的严重性密切相关.
目的 探討新生兒先天性心髒病患兒是否存在內皮素1 (ET-1)和心房利鈉肽(ANP)的明顯激活及其臨床意義.方法 選取100例新生兒先天性心髒病患兒(按心功能分級標準將患者分成幾箇亞組:Ⅰ級組30例、Ⅱ級組40例、Ⅲ-Ⅳ級組30例),併選取年齡、性彆與之相匹配的正常體檢新生兒30名作為對照組.檢測其ET-1、ANP濃度.結果 新生兒先天性心髒病Ⅲ-Ⅳ級組患兒血循環中的ET-1為(132.35±5.26) ng/L、ANP為(9.25±2.37) pmol/L,與對照組[ET-1(53.62±3.81) ng/L、ANP(1.15±0.09) pmol/L]比較明顯增高(P＜0.01).3箇亞組隨著疾病嚴重程度的加重,ET-1、ANP的激活就越明顯,ET-1與心功能分級呈明顯正相關(r=0.35;P ＜0.01);ANP與心功能分級呈明顯正相關(r =0.72,P＜0.01).結論 新生兒先天性心髒病患兒的ET-1、ANP明顯激活,併具有慢性心力衰竭的特徵,其與疾病的嚴重性密切相關.
목적 탐토신생인선천성심장병환인시부존재내피소1 (ET-1)화심방리납태(ANP)적명현격활급기림상의의.방법 선취100례신생인선천성심장병환인(안심공능분급표준장환자분성궤개아조:Ⅰ급조30례、Ⅱ급조40례、Ⅲ-Ⅳ급조30례),병선취년령、성별여지상필배적정상체검신생인30명작위대조조.검측기ET-1、ANP농도.결과 신생인선천성심장병Ⅲ-Ⅳ급조환인혈순배중적ET-1위(132.35±5.26) ng/L、ANP위(9.25±2.37) pmol/L,여대조조[ET-1(53.62±3.81) ng/L、ANP(1.15±0.09) pmol/L]비교명현증고(P＜0.01).3개아조수착질병엄중정도적가중,ET-1、ANP적격활취월명현,ET-1여심공능분급정명현정상관(r=0.35;P ＜0.01);ANP여심공능분급정명현정상관(r =0.72,P＜0.01).결론 신생인선천성심장병환인적ET-1、ANP명현격활,병구유만성심력쇠갈적특정,기여질병적엄중성밀절상관.
Objective To investigate the role of atrial natriuretic peptide(ANP) and endothelin 1 (ET-1) of newborns with congenital heart failure and its clinical significance.Methods One hundred newborns with congenital heart disease were selected as our subjects.They were divided into 3 groups according to cardiac function grading criteria and that were grade Ⅰ group(30 cases),grade Ⅱ group(40 cases) and grade Ⅲ-Ⅳ group(30 cases).Another 30 normal newborns were served as control group matched with age,gender.ET-1,ANP were detected.Results The levels of ET-1 and ANP in newborns of grade Ⅲ-Ⅳ were (132.35 ±5.26) ng/L and (9.25 ± 2.37) pmol/L,significant higher than that in control group((53.62 ± 3.81) ng/L and (1.15 ±0.09) pmol/L;P ＜0.01).As the severity of the disease in newborns with congenital heart failure,the level of ET-1,ANP were activated more.There was a positive correlation between ET-1 and grade of cardiac function (r =0.35,P ＜ 0.01).Meanwhile,it also showed a positive correlation between ANP and cardiac function (r =0.72,P ＜ 0.01).Conclusion ET-1,ANP in newborns with congenital heart disease are activated with characterized of chronic heart failure,and related to severity of the disease.
