CAJ | 학술논문

目的：检测XAGE-1b在腺样囊性癌（adenoid cystic carcinoma， ACC）组织和正常涎腺组织中的表达，并探讨XAGE-1b的表达在ACC发生发展中的作用。方法：应用免疫组织化学方法检测40例ACC组织和正常涎腺组织中XAGE-1b的表达，分析其与临床病理的关系。结果：ACC组织中XAGE-1 b阳性表达率显著高于正常涎腺组织（ P＜0．05）；XAGE-1 b表达与TNM分期、肿瘤直径及淋巴结转移有关（P＜0．05），而与患者年龄、性别无关（P＞0．05）。结论：XAGE-1b异常表达与ACC的发生、转移及预后密切相关，检测XAGE-1b的表达有望成为ACC的早期诊断、预后评估的分子指标，为进一步探讨涎腺腺样囊性癌的致病机制及意义提供了理论基础和实验依据。
목적：검측XAGE-1b재선양낭성암（adenoid cystic carcinoma， ACC）조직화정상연선조직중적표체，병탐토XAGE-1b적표체재ACC발생발전중적작용。방법：응용면역조직화학방법검측40례ACC조직화정상연선조직중XAGE-1b적표체，분석기여림상병리적관계。결과：ACC조직중XAGE-1 b양성표체솔현저고우정상연선조직（ P＜0．05）；XAGE-1 b표체여TNM분기、종류직경급림파결전이유관（P＜0．05），이여환자년령、성별무관（P＞0．05）。결론：XAGE-1b이상표체여ACC적발생、전이급예후밀절상관，검측XAGE-1b적표체유망성위ACC적조기진단、예후평고적분자지표，위진일보탐토연선선양낭성암적치병궤제급의의제공료이론기출화실험의거。
Objective:To detected the expression of Tiam1 and XAGE-1b in ACC and normal salivary gland tissue and investigated the correlation of the two genes with ACC stage , tumor size , lymph node metastasis , patient age and gender .Methods:Immunohistochem-istry was used to detect the expression of KAI 1 and Tiam1 in 40 cases of ACC and normal salivary gland tissues .Results:The Tiam1 and XAGE-1b positive expression rate was significantly higher than that in normal salivary gland tissue (P<0.05);the expression of Tiam1 and XAGE-1b was related with TNM stage , tumor size and lymph node metastasis (P<0.05), these two genes’s expression was no re-lationship with the patient's age and gender(P>0.05); between the two proteins positive expression was positively correlated (P <0. 05).Conclusion:Tiam1 XAGE-1b and the occurrence of abnormal expression of ACC , metastasis and prognosis, the joint detection of the expression of KAI 1 and Tiam1 is expected to become the ACC's early diagnosis , prognostic molecular markers .To further explore the adenoid cystic carcinoma of the pathogenic mechanism and significance of providing a theoretical basis and experimental evidence .