CAJ | 학술논문

目的：运用Meta分析方法综合分析动脉瘤性蛛网膜下腔出血致迟发性脑血管痉挛（DCVS）的相关危险因素，为疾病的预防、治疗决策提供依据。方法用关键词途径从维普中文科技期刊、中国知网和万方以及Pubmed、Springlink和 Highwire等外文数据库收录有关动脉瘤性蛛网膜下腔出血致DCVS相关危险因素的文献进行检索，经严格筛选后对最后纳入的文献用RevMan5．1软件进行Meta分析。结果共纳入13篇文献，经检验所有数据均均衡，采用固定效应模式进行Meta分析。高血压病史、Fisher分级（＞2级）、年龄（＞50岁）、动脉瘤位置（后循环）差异有统计学意义（ P＜0．05），性别（男性）、吸烟史、手术方式（夹闭）差异无统计学意义（P＞0．05）。数据漏斗图分析对称，提示文献无发表偏倚。结论有高血压病史、Fisher分级（＞2级）、年龄（＜50岁）、动脉瘤位置（后循环）的患者更易发生DCVS ，临床上应对此类患者加强监测与管理。
목적：운용Meta분석방법종합분석동맥류성주망막하강출혈치지발성뇌혈관경련（DCVS）적상관위험인소，위질병적예방、치료결책제공의거。방법용관건사도경종유보중문과기기간、중국지망화만방이급Pubmed、Springlink화 Highwire등외문수거고수록유관동맥류성주망막하강출혈치DCVS상관위험인소적문헌진행검색，경엄격사선후대최후납입적문헌용RevMan5．1연건진행Meta분석。결과공납입13편문헌，경검험소유수거균균형，채용고정효응모식진행Meta분석。고혈압병사、Fisher분급（＞2급）、년령（＞50세）、동맥류위치（후순배）차이유통계학의의（ P＜0．05），성별（남성）、흡연사、수술방식（협폐）차이무통계학의의（P＞0．05）。수거루두도분석대칭，제시문헌무발표편의。결론유고혈압병사、Fisher분급（＞2급）、년령（＜50세）、동맥류위치（후순배）적환자경역발생DCVS ，림상상응대차류환자가강감측여관리。
Objective To systematically analyze the risk factors for de1ayed cerebral vasospasm after aneurysm subarachnoid hemorrhage in order to provide evidence for prevention and treatment of the disease .Methods Articles of risk factors for de1ayed cerebral vasospasm after aneurysm subarachnoid hemorrhage from VIP ,CBM ,CNKI ,Wangfang and pubmed ,springlink ,highwire database ,and correlated indexes were extracted for Meta‐analysis by using RevMan 5 .1 .Results Thirteen articles were selected . The heterogeneity of all data was equilibrium ,and used fixed effects model .The difference showed statistical significance in the his‐tory of hypertension ,Fisher > Ⅱ ,age>50 years and the posterior circulation aneurysm (P<0 .05) .and no statistical significance in the sex ,smoking history ,the way of treatment(P>0 .05) .The symmetry of funnel plots prompted no publication bias .Conclusion Patients with history of hypertension ,Fisher > Ⅱ ,age< 50 years and the posterior circulation aneurysm are at higher risk of de1ayed cerebral vasospasm ,strengthen close monitoring and management are crucial in these patients .