CAJ | 학술논문

目的：探讨术前间质化疗对高分化口腔鳞状细胞癌（OSCC ）中Ki‐67和Caspase‐3蛋白表达的影响及其意义。方法高分化OSCC 60例分为术前未化疗组（30例）、术前静脉化疗组（15例）、术前间质化疗组（15例），均采用免疫组织化学 PV‐6000通用型二步法检测Ki‐67和Caspase‐3蛋白的表达，各组之间进行比较。结果 OSCC组织中Ki‐67蛋白标记指数在术前未化疗组、术前静脉化疗组、术前间质化疗组比较差异均有统计学意义（P＜0．05），癌旁黏膜中3组比较差异有统计学意义（P＜0．05）；Caspase‐3蛋白表达在3组之间比较差异有统计学意义（P＜0．05）。结论 OSCC中术前间质化疗较静脉化疗相比更能有效抑制细胞增殖及诱导细胞凋亡，从而抑制肿瘤生长。
목적：탐토술전간질화료대고분화구강린상세포암（OSCC ）중Ki‐67화Caspase‐3단백표체적영향급기의의。방법고분화OSCC 60례분위술전미화료조（30례）、술전정맥화료조（15례）、술전간질화료조（15례），균채용면역조직화학 PV‐6000통용형이보법검측Ki‐67화Caspase‐3단백적표체，각조지간진행비교。결과 OSCC조직중Ki‐67단백표기지수재술전미화료조、술전정맥화료조、술전간질화료조비교차이균유통계학의의（P＜0．05），암방점막중3조비교차이유통계학의의（P＜0．05）；Caspase‐3단백표체재3조지간비교차이유통계학의의（P＜0．05）。결론 OSCC중술전간질화료교정맥화료상비경능유효억제세포증식급유도세포조망，종이억제종류생장。
Objective To discuss the preoperative interstitial chemotherapy effect and significance on Ki‐67 and Caspase‐3 in oral squamous cell carcinoma .Methods 60 cases of well‐differentiated oral squamous cell carcinoma were divided into three groups ,non chemotherapy before operation group(n= 30) ,intravenous chemotherapy before operation group (n= 15) and interstitial chemo‐therapy before operation group(n=15) .The expressions of Ki‐67 and Caspase‐3 were determined by immunohistochemical method , then compared between three groups .Results The labelling index of Ki‐67 in tissue of carcinoma were significant differences a‐mong each groups(P< 0 .05) .The labelling index of Ki‐67 in adjacent mucosas of carcinoma were significant differences among three groups(P<0 .05) .The expression rates of Caspase‐3 were significant differences among three groups(P<0 .05) .Conclusion Preoperative interstitial chemotherapy than preoperative intravonous chemotherapy for oral squamous carcinoma more inhibit tumor growth and reduce local recurrence through the inhibition of cell proliferation and induction of cell apoptosis ,thus inhibiting tumor growth .