CAJ | 학술논문

目的：系统评价中国新生儿呼吸机相关性肺炎（VAP）的危险因素，为临床制订预防策略提供依据。方法检索PubMed、WebofScience、中国知网（CNKI）、中国生物医学文摘数据库（CBM）、重庆维普（VIP）和万方数据库，收集研究中国新生儿VAP危险因素的文献，按照纳入和排除标准筛选文献、提取数据并采用Revman5．1软件进行Meta分析。结果根据纳入排除标准，最终纳入20篇文献，病例1145例，对照2610例。影响新生儿发生VAP的危险因素包括机械通气（MV）≥3d、原发性肺部疾病、头部仰卧位、鼻胃管、早产、重插管、低体质量、血制品应用、剖宫产及肠外营养。结论临床上应针对中国新生儿VAP发病的相关危险因素采取针对性预防措施，从而降低VAP的发病率和病死率。
목적：계통평개중국신생인호흡궤상관성폐염（VAP）적위험인소，위림상제정예방책략제공의거。방법검색PubMed、WebofScience、중국지망（CNKI）、중국생물의학문적수거고（CBM）、중경유보（VIP）화만방수거고，수집연구중국신생인VAP위험인소적문헌，안조납입화배제표준사선문헌、제취수거병채용Revman5．1연건진행Meta분석。결과근거납입배제표준，최종납입20편문헌，병례1145례，대조2610례。영향신생인발생VAP적위험인소포괄궤계통기（MV）≥3d、원발성폐부질병、두부앙와위、비위관、조산、중삽관、저체질량、혈제품응용、부궁산급장외영양。결론림상상응침대중국신생인VAP발병적상관위험인소채취침대성예방조시，종이강저VAP적발병솔화병사솔。
Objective To provide references for VAP prevention strategy through systematically review on the risk factors of neonatal ventilator‐associated pneumonia(VAP) in China .Methods Literatures of neonatal VAP were searched in PubMed ,Web of Science ,CNKI ,CBM ,VIP and WanFang databases .Literatures screening and data extraction were conducted according to the inclu‐sion and exclusion criteria .Meta‐analysis were calculated using software Revman5 .1 .Results 20 studies were included .1 145 cases of Patients and 2 610 cases in cantrol group .The 10 possible risk factors related to neonatal VAP were MV ≥3 days ,underlying lung disease ,supine ,nasal feeding and gastric tube ,preterm delivery ,reintubation ,underweight ,transfusion ,cesarean delivery and parenteral nutrition .Conclusion The targeted methods considering the above factors should be taken to decrease the morbidity and mortality of VAP in China .