CAJ | 학술논문

目的：探讨单独或联合应用盐酸帕罗西汀和盐酸坦索罗辛治疗原发性早泄（P E ）的疗效及不良反应。方法筛选本院男科门诊 PE患者225例，分成 A、B和C组，每组75例。A组单用盐酸帕罗西汀，20 mg/d。B组单用盐酸坦索罗辛，0．4 mg/d。C组同时服用盐酸帕罗西汀和盐酸坦索罗辛，剂量同A、B组。采用问卷调查比较3组患者治疗8周后与治疗前的平均阴道内射精潜伏期（IELT ）以及早泄量表（PEP）中各项指标的改变情况，并对治疗期间的不良反应进行了总结。结果共获得198例可靠随访数据，3组患者平均IELT在治疗后较治疗前均显著增加（P＜0．05），C组治疗后IELT 均值增加了8．15 min；治疗后增加的倍数（8．02倍）显著高于B组（1．98倍）和A组（6．92倍）（ P＜0．05）。3组患者早泄量表中射精控制能力、性交满意度、早泄相关苦恼及早泄相关两性沟通困难4项指标评分的平均值，在治疗后较治疗前均有显著提高；而C组4项指标的均值提高更为显著。A、B、C组患者出现的不良反应分别为10例（13．3％）、2例（2．6％）、9例（12．0％）。结论盐酸帕罗西汀和盐酸坦索罗辛联合应用治疗PE的有效性、安全性较好。
목적：탐토단독혹연합응용염산파라서정화염산탄색라신치료원발성조설（P E ）적료효급불량반응。방법사선본원남과문진 PE환자225례，분성 A、B화C조，매조75례。A조단용염산파라서정，20 mg/d。B조단용염산탄색라신，0．4 mg/d。C조동시복용염산파라서정화염산탄색라신，제량동A、B조。채용문권조사비교3조환자치료8주후여치료전적평균음도내사정잠복기（IELT ）이급조설량표（PEP）중각항지표적개변정황，병대치료기간적불량반응진행료총결。결과공획득198례가고수방수거，3조환자평균IELT재치료후교치료전균현저증가（P＜0．05），C조치료후IELT 균치증가료8．15 min；치료후증가적배수（8．02배）현저고우B조（1．98배）화A조（6．92배）（ P＜0．05）。3조환자조설량표중사정공제능력、성교만의도、조설상관고뇌급조설상관량성구통곤난4항지표평분적평균치，재치료후교치료전균유현저제고；이C조4항지표적균치제고경위현저。A、B、C조환자출현적불량반응분별위10례（13．3％）、2례（2．6％）、9례（12．0％）。결론염산파라서정화염산탄색라신연합응용치료PE적유효성、안전성교호。
Objective To evaluate the therapeutic effects and adverse events on treatment of primary premature ejaculation (PE) with paroxetine hydrochloride and/or tamsalosin .Methods 225 cases of healthy men ,a history of lifelong PE and an intravaginal e‐jaculation latency time(IELT) < 120 sec were included in this study .The patients were divided into three groups(with 75 cases in each group) .Group A were given paroxetine hydrochloride 20 mg/d for 8 weeks ;group B were given tamsalosin 0 .2 mg/d for 8 weeks ;group C were given paroxetine hydrochloride and tamsalosin for 8 weeks .The effects and adverse events were evaluated by the overall change and fold increase in average IELT and the mean change in all four measures of the premature ejaculation profile (PEP) .Results The reliable data from 198 patients were achieved .The mean IELT after treatment were significantly improved in all groups than that of before treatment (P<0 .05) .The mean IELT in group C was increased for 8 .15 min after treatment .The in‐creased folds of mean IELT in group C (8 .02 folds) was significantly higher than that in group B (1 .98 folds)and group A (6 .92 folds)(P<0 .01) .The mean PEP scores that include measures of perceived control over ejaculation ,satisfaction with sexual inter‐course ,ejaculation‐related personal distress ,ejaculation‐related interpersonal difficulty were significantly improved in all groups after treatment .The mean PEP scores in group C had more significant improvements than that in group A and B .The prevalence of ad‐verse events in group A ,B ,C were 10 cases(13 .3% ) ,2 cases(2 .6% ) and 9 cases(12 .0% ) ,respectively .Conclusion Paroxetine hydrochloride combined with tamsalosin lead to better therapeutic effects and could be a priority selection for the treatment of pri‐mary PE .