CAJ | 학술논문

目的：探讨帕金森病（PD）患者血清中主要炎症因子IL‐1β、IL‐6、肿瘤坏死因子α（TNF‐α）和干扰素γ（IFN‐γ）水平的变化及其与病程、疾病严重程度的相关性。方法采集56例PD患者及120例健康者（对照组）的血液样本，采用ELISA检测血清中的IL‐1β、IL‐6、TNF‐α和IFN‐γ的水平。结果PD患者血清IL‐1β、IL‐6及TNF‐α水平显著高于对照组（P＜0．01），血清IFN‐γ水平差异无统计学意义（P＝0．86）。PD患者血清炎症因子水平与病程、Hoen&Yahr分期、Schwab&England日常活动分级评分均无相关性（P＞0．05）。结论炎症参与了PD的病理过程，血清炎症因子与病程和疾病严重程度均无相关性。
목적：탐토파금삼병（PD）환자혈청중주요염증인자IL‐1β、IL‐6、종류배사인자α（TNF‐α）화간우소γ（IFN‐γ）수평적변화급기여병정、질병엄중정도적상관성。방법채집56례PD환자급120례건강자（대조조）적혈액양본，채용ELISA검측혈청중적IL‐1β、IL‐6、TNF‐α화IFN‐γ적수평。결과PD환자혈청IL‐1β、IL‐6급TNF‐α수평현저고우대조조（P＜0．01），혈청IFN‐γ수평차이무통계학의의（P＝0．86）。PD환자혈청염증인자수평여병정、Hoen&Yahr분기、Schwab&England일상활동분급평분균무상관성（P＞0．05）。결론염증삼여료PD적병리과정，혈청염증인자여병정화질병엄중정도균무상관성。
Objective To compare the serum levels of interleukin(IL)‐1β,IL‐6 ,tumor necrosis factor alpha(TNF‐α) and inter‐feron gamma(IFN‐γ) in patients with Parkinson′s disease(PD) and healthy controls .To analyze the correlations of serum inflamma‐tory factors with disease duration and severity .Methods Peripheral blood samples were collected from 56 PD patients and 120 healthy controls .Serum levels of IL‐1β,IL‐6 ,TNF‐αand IFN‐γwere measured using highly sensitive enzyme linked immunosorbent assay(ELISA) kits .Results Serum levels of IL‐1β,IL‐6 ,TNF‐α were significantly higher in PD patients than in healthy controls (all P<0 .01) ,serum levels of IFN‐γ were not significantly different between PD patients and healthy controls (P=0 .86) .Serum levels of these inflammatory cytokines were not significantly correlated with the disease ,duration ,Hoen & Yahr ,Schwab & Eng‐land scores(P>0 .05) .Conclusion Our results indicate that serum inflammatory factors are altered in PD patients .However ,serum inflammatory factors were not correlated with disease duration and severity .