CAJ | 학술논문

目的：探讨多药耐药相关蛋白MRP（multidrug resistance associated protein，MRP）和肺耐药相关蛋白（lung resistance protein，LRP）在非小细胞肺癌中的基因表达及与顺铂耐药的关系。方法搜集化疗前后均有标本的非小细胞肺癌患者13例，应用RT-PCR法检测化疗前后MRP和LRP基因表达， Logistic回归分析法分析2种蛋白基因表达的相关性。结果与顺铂化疗前相比，化疗后患者MRP基因和LRP基因表达均显著增高（P＜0.05）；Logistic回归分析显示，2种蛋白的基因表达不具有相关性（r=0.036，P＜0.05）。结论应用顺铂化疗后MRP和LRP基因表达增高，且2种蛋白的基因表达不具有相关性。
목적：탐토다약내약상관단백MRP（multidrug resistance associated protein，MRP）화폐내약상관단백（lung resistance protein，LRP）재비소세포폐암중적기인표체급여순박내약적관계。방법수집화료전후균유표본적비소세포폐암환자13례，응용RT-PCR법검측화료전후MRP화LRP기인표체， Logistic회귀분석법분석2충단백기인표체적상관성。결과여순박화료전상비，화료후환자MRP기인화LRP기인표체균현저증고（P＜0.05）；Logistic회귀분석현시，2충단백적기인표체불구유상관성（r=0.036，P＜0.05）。결론응용순박화료후MRP화LRP기인표체증고，차2충단백적기인표체불구유상관성。
Objective To investigate the mRNA expression of the multidrug resistance associated protein and lung resistance protein in human non-small cell lung cancer tissues and their relationship with cis-platinum. Methods 13 samples were collected from patients with non small cell lung cancer before and after chemotherapy, the mRNA expression of MRP and LRP were detected using RT-PCR method, correlation between two genes were studied by Logistic regression analysis. Results Compared with before cisplatin chemotherapy, MRP and LRP expression of patients were increased after chemotherapy(P<0.05).Logistic regression analysis showed that there is no correlation between the two genes(r=0.036,P<0.05). Conclusion Cisplatin chemotherapy can increase the mRNA expression of MRP and LRP, and there is no correlation between the two genes.