中国生化药物杂志
中國生化藥物雜誌
중국생화약물잡지
CHINESE JOURNAL OF BIOCHEMICAL PHARMACEUTICS
2014年
2期
106-107,109
,共3页
短暂性脑缺血发作%补阳还五汤%阿司匹林抵抗
短暫性腦缺血髮作%補暘還五湯%阿司匹林牴抗
단잠성뇌결혈발작%보양환오탕%아사필림저항
transient ischemic attack%Buyanghuanwu decotion%aspirin resistance
目的：对比观察补阳还五汤联合阿司匹林治疗短暂性脑缺血发作（transient ischemic attack，TIA）时阿司匹林抵抗的临床疗效。方法参照标准选取潍坊医学院附属医院2010年9月～2013年10月收治的TIA患者80例，分为实验组（n=40）与对照组（n=40）。实验组口服补阳还五汤和阿司匹林治疗，对照组患者服用氯吡格雷和阿司匹林治疗，采用比浊法分别检测各研究对象治疗前、治疗第30天、治疗第60天及治疗第90天的花生四烯酸（arachidonic acid，AA）和二磷酸腺苷（adenosine diphosphate，ADP）水平，随访观察2组治疗期间各时间段的TIA复发例数、脑梗死例数及不良反应事件（如皮肤黏膜出血、便血等）的发生情况。结果2组患者治疗第30天、治疗第60天及治疗第90天的ADP和AA值与治疗前相比均显著下降（P<0.05）。实验组治疗前、治疗第30天、治疗第60天及治疗第90天的ADP和AA值与对照组相比均无统计学差异；2组治疗90天内的复发率、脑梗死率与对照组均无统计学差异；2组治疗期间发生不良反应情况存在统计学差异（P<0.05）。结论补阳还五汤联合阿司匹林治疗短暂性脑缺血发作时阿司匹林抵抗的临床疗效与氯吡格雷联合阿司匹林治疗相当，但可降低不良反应事件的发生率。
目的：對比觀察補暘還五湯聯閤阿司匹林治療短暫性腦缺血髮作（transient ischemic attack，TIA）時阿司匹林牴抗的臨床療效。方法參照標準選取濰坊醫學院附屬醫院2010年9月～2013年10月收治的TIA患者80例，分為實驗組（n=40）與對照組（n=40）。實驗組口服補暘還五湯和阿司匹林治療，對照組患者服用氯吡格雷和阿司匹林治療，採用比濁法分彆檢測各研究對象治療前、治療第30天、治療第60天及治療第90天的花生四烯痠（arachidonic acid，AA）和二燐痠腺苷（adenosine diphosphate，ADP）水平，隨訪觀察2組治療期間各時間段的TIA複髮例數、腦梗死例數及不良反應事件（如皮膚黏膜齣血、便血等）的髮生情況。結果2組患者治療第30天、治療第60天及治療第90天的ADP和AA值與治療前相比均顯著下降（P<0.05）。實驗組治療前、治療第30天、治療第60天及治療第90天的ADP和AA值與對照組相比均無統計學差異；2組治療90天內的複髮率、腦梗死率與對照組均無統計學差異；2組治療期間髮生不良反應情況存在統計學差異（P<0.05）。結論補暘還五湯聯閤阿司匹林治療短暫性腦缺血髮作時阿司匹林牴抗的臨床療效與氯吡格雷聯閤阿司匹林治療相噹，但可降低不良反應事件的髮生率。
목적：대비관찰보양환오탕연합아사필림치료단잠성뇌결혈발작（transient ischemic attack，TIA）시아사필림저항적림상료효。방법삼조표준선취유방의학원부속의원2010년9월～2013년10월수치적TIA환자80례，분위실험조（n=40）여대조조（n=40）。실험조구복보양환오탕화아사필림치료，대조조환자복용록필격뢰화아사필림치료，채용비탁법분별검측각연구대상치료전、치료제30천、치료제60천급치료제90천적화생사희산（arachidonic acid，AA）화이린산선감（adenosine diphosphate，ADP）수평，수방관찰2조치료기간각시간단적TIA복발례수、뇌경사례수급불량반응사건（여피부점막출혈、편혈등）적발생정황。결과2조환자치료제30천、치료제60천급치료제90천적ADP화AA치여치료전상비균현저하강（P<0.05）。실험조치료전、치료제30천、치료제60천급치료제90천적ADP화AA치여대조조상비균무통계학차이；2조치료90천내적복발솔、뇌경사솔여대조조균무통계학차이；2조치료기간발생불량반응정황존재통계학차이（P<0.05）。결론보양환오탕연합아사필림치료단잠성뇌결혈발작시아사필림저항적림상료효여록필격뢰연합아사필림치료상당，단가강저불량반응사건적발생솔。
Objective To observe and compare the clinical efifcacy of buyanghuanwu decotion combined with aspirin in treatment of aspirin resistance when transient ischemic attack(TIA). Methods 80 patients with TIA from September 2010 to October 2013 in Affiliated Hospital of Weifang Medical College were selected according to the standards and divided into two groups, with 40 cases in each group. Experimental group were orally administered with buyanghuanwu decotion and aspirin. Control group were orally administered with clopidogrel and aspirin. The levels of arachidonic acid (AA) and adenosine diphosphate (ADP) before therapy and in the 60 th and 90 th treatment day were detected by turbidimetry, respectively. Follow-up studies were performed to observe the recurrence numbers of TIA, cerebral infarction cases and adverse events, such as mucocutaneous hemorrhage and hemafacia in two groups during therapy. Results The levels of AA and ADP were decreased constantly with the therapy time in both two groups. The levels of ADP and AA in experimental group before therapy and in the 60 th and 90 th treatment day were not signiifcantly different from those in control group. No signiifcant differences of reoccurrence rate and the cerebral infarction rate were found between the two groups. However, there was statically signiifcant difference in the occurrence of adverse events between the two groups (P<0.05). Conclusion The clinical efifcacy of the combined treatment of buyanghuanwu decotion with aspirin shows no signiifcant difference with the combined treatment of clopidogrel and aspirin, but with lower incidence rate of adverse events.
