CAJ | 학술논문

细胞色素P 4501 A 1（cytochrome P 4501 A 1，CYP1 A 1）、细胞色素P 4501 B 1（cytochrome P 4501 B 1，CYP1 B 1）、血管内皮细胞生长因子(vascular endothelial growth factor，VEGF)以及碳酸酐酶Ⅸ（carbonic anhydrase Ⅸ，CAⅨ）分别是芳香族化合物受体(aryl hydrocarbon receptor,AhR）信号通路和缺氧诱导因子(hypoxia inducible factor，HIF-1)信号通路的下游基因，这些基因的异常表达被认为与肺癌的发生、发展及血管的形成有着密切的关系。本文对CYP1 A 1、CYP1 B 1、VEGF、CAⅨ与肺癌的关系进行综述，旨在于为肺癌研究提供新思路。
세포색소P 4501 A 1（cytochrome P 4501 A 1，CYP1 A 1）、세포색소P 4501 B 1（cytochrome P 4501 B 1，CYP1 B 1）、혈관내피세포생장인자(vascular endothelial growth factor，VEGF)이급탄산항매Ⅸ（carbonic anhydrase Ⅸ，CAⅨ）분별시방향족화합물수체(aryl hydrocarbon receptor,AhR）신호통로화결양유도인자(hypoxia inducible factor，HIF-1)신호통로적하유기인，저사기인적이상표체피인위여폐암적발생、발전급혈관적형성유착밀절적관계。본문대CYP1 A 1、CYP1 B 1、VEGF、CAⅨ여폐암적관계진행종술，지재우위폐암연구제공신사로。
Cytochrome P 4501 A 1, Cytochrome P 4501 B 1,Vascular endothelial growth factorand carbonic anhydrase Ⅸ belong to the downstream genes of aryl hydrocarbon receptor (AhR)and hypoxia inducible factor 1(HIF-1)signaling pathways. The abnormal expression of those genes were regarded to associated with the occurrence,development and angiogenesis of lung cancer. In this paper, the relationship between CYP1 A 1,CYP1 B 1,VEGF,CAⅨgenes and lung cancer was summarized, which aims to provide new ideas for lung cancer research.