CAJ | 학술논문

研究了利用辛可尼丁和L‐脯氨酸复合催化体系促进含三氟甲基芳香亚胺1的不对称异构化反应，并详细考察了不同种类的有机催化剂、溶剂以及添加剂对反应产率与选择性的影响。结果表明，当以四氢呋喃作溶剂，2‐环己烯‐1‐酮为添加剂时，反应的分离产率与立体选择性最好，可以达到64％的产率，68％的ee值。
연구료이용신가니정화L‐포안산복합최화체계촉진함삼불갑기방향아알1적불대칭이구화반응，병상세고찰료불동충류적유궤최화제、용제이급첨가제대반응산솔여선택성적영향。결과표명，당이사경부남작용제，2‐배기희‐1‐동위첨가제시，반응적분리산솔여입체선택성최호，가이체도64％적산솔，68％적ee치。
In this work ,it is found that the composite catalyst system of cinchonidine and L‐proline can promote the asymmetric isomerization reaction containing trifluoromethyl aromatic imine .The paper investigates the effects of different organocatalysts ,solvents and additives on the reaction yield and selectivity .The results show that the reaction has optimal separation yield and stereoselectivity with tetrahydrofuran as the solvent and 2‐cyclohexene‐1‐ketone as the additive ,the yield can up to 64% and ee value can up to 68% .