CAJ | 학술논문

对医用镁可降解高分子基复合材料表面改性技术进行了探索研究，以提高镁在生理环境下的耐蚀性及其表面的生物相容性。采用环氧氯丙烷-丙酮混合溶剂在高纯镁上制备了 L-聚乳酸(PLLA)涂层，再分别以MgO和Mg(OH)2为增强相，制备了PLLA基复合涂层。使用扫描电镜、耐蚀性快速检测、涂层/基体结合力测试、电化学动电位极化曲线测量以及体外生物降解行为研究对涂层进行综合分析。结果表明，适量 MgO 或Mg(OH)2增强相的添加均能显著提高PLLA涂层在Hank’s模拟体液中的降解防护性能，并有利于降低 PLLA 生物降解所产生的酸化效应。
대의용미가강해고분자기복합재료표면개성기술진행료탐색연구，이제고미재생리배경하적내식성급기표면적생물상용성。채용배양록병완-병동혼합용제재고순미상제비료 L-취유산(PLLA)도층，재분별이MgO화Mg(OH)2위증강상，제비료PLLA기복합도층。사용소묘전경、내식성쾌속검측、도층/기체결합력측시、전화학동전위겁화곡선측량이급체외생물강해행위연구대도층진행종합분석。결과표명，괄량 MgO 혹Mg(OH)2증강상적첨가균능현저제고PLLA도층재Hank’s모의체액중적강해방호성능，병유리우강저 PLLA 생물강해소산생적산화효응。
The surface modification of magnesium alloys by bio-degradable polymer matrix composites for biomedical applications was studied to improve both corrosion resistance and surface biocompatibility of magnesium under physiological conditions. A poly(L-lactic acid) (PLLA) coating was formed on high-purity magnesium substrate with epichlorohydrin and acetone as solvent, and two PLLA matrix composite coatings were prepared with MgO and Mg(OH)2 as reinforcement respectively. The comprehensive performances of the coatings were evaluated by scanning electron microscopy, rapid corrosion resistance test, coating/substrate adhesion test, potentiodynamic polarization measurement, and in vitro biodegradation behavior studies. The results showed that adding an appropriate amount of MgO or Mg(OH)2 as reinforcement can improve the resistance of PLLA coating to degradation in Hank’s simulated body fluid, and reduce the acidification during the dissolution of PLLA.