CAJ | 학술논문

目的：探讨儿科下呼吸道细菌分布和耐药性分析，为临床合理用药提供依据。方法收集该院住院患儿的下呼吸道分泌物标本，分离、鉴定细菌，并进行药敏试验。结果4290例下呼吸道分泌物培养获得阳性标本1653例，阳性率38.5%；其中革兰氏阳性球菌441例占阳性标本26.7%，革兰氏阴性菌1212例占阳性标本73.3%。分布比位居前5位菌株为克雷伯菌、大肠埃希菌、肺炎链球菌、金黄色葡萄球菌和阴沟肠杆菌，对多数抗生素均具有较高耐药性，在春季和冬季分布比例较高。结论儿科下呼吸道主要细菌具有多药耐药性，临床应根据病原菌的分布和耐药性，合理使用抗菌药物。
목적：탐토인과하호흡도세균분포화내약성분석，위림상합리용약제공의거。방법수집해원주원환인적하호흡도분비물표본，분리、감정세균，병진행약민시험。결과4290례하호흡도분비물배양획득양성표본1653례，양성솔38.5%；기중혁란씨양성구균441례점양성표본26.7%，혁란씨음성균1212례점양성표본73.3%。분포비위거전5위균주위극뢰백균、대장애희균、폐염련구균、금황색포도구균화음구장간균，대다수항생소균구유교고내약성，재춘계화동계분포비례교고。결론인과하호흡도주요세균구유다약내약성，림상응근거병원균적분포화내약성，합리사용항균약물。
Objective To study the distribution and drug resistance of bacteria of lower respiratory tract in department of pediatrics and provide a basis for clinical reasonable medication. Methods The specimens of lower respiratory tract secretion of children hos-pitalized in our hospital in 2012 were collected, and the bacteria were separated, identified and given drug sensitive tests. Results 1653 positive specimens (positive rate 38.5%) were isolated from 4290 cases of secretion cultivation of lower respiratory tract, in-cluding 441 cases of gram-positive cocci (26.7%) and 1212 cases of gram-negative germ (73.3%). The former five bacteria in dis-tribution were klebsiella, escherichia coli, streptococcus pneumoniae, staphylococcus aureus and enterobacter cloacae, which had high drug resistance to most antibiotics and had higher distribution rates in spring and winter. Conclusion The main bacteria of lower respiratory tract in department of pediatrics have multidrug resistance. We should choose antibiotics reasonably according to the distribution and drug resistance in clinical work.