CAJ | 학술논문

目的探讨美托洛尔注射液对冠状动脉（冠脉）心肌桥的影响，临床疗效和安全性。方法选择2011年5月至2013年5月心内科住院，通过冠脉造影确诊为冠脉心肌桥患者72例，观察并比较静脉注射美托洛尔注射液5，10 min后患者血压、心率及心肌桥收缩期狭窄程度的变化用配对t检验比较。结果用药前与用药后相比美托洛尔使冠脉狭窄程度由用药前的70．0％±18．2％降至用药后的46．4％±18．5％（t ＝7．701， P＜0．01）；心率由（75．5±7．0）次/min下降至（65．3±6．8）次/min （t＝8．814， P＜0．01）；收缩压由（139±16）mmHg下降至（128±14）mmHg （t ＝4．280， P＜0．01），舒张压由（75±8） mmHg下降至（66±4） mmHg （t ＝7．967， P＜0．01），用药前后相比差异均有统计学意义。结论美托洛尔注射液治疗心肌桥是有效的安全的，可以减轻心肌桥对冠脉的压迫使狭窄程度减轻。
목적탐토미탁락이주사액대관상동맥（관맥）심기교적영향，림상료효화안전성。방법선택2011년5월지2013년5월심내과주원，통과관맥조영학진위관맥심기교환자72례，관찰병비교정맥주사미탁락이주사액5，10 min후환자혈압、심솔급심기교수축기협착정도적변화용배대t검험비교。결과용약전여용약후상비미탁락이사관맥협착정도유용약전적70．0％±18．2％강지용약후적46．4％±18．5％（t ＝7．701， P＜0．01）；심솔유（75．5±7．0）차/min하강지（65．3±6．8）차/min （t＝8．814， P＜0．01）；수축압유（139±16）mmHg하강지（128±14）mmHg （t ＝4．280， P＜0．01），서장압유（75±8） mmHg하강지（66±4） mmHg （t ＝7．967， P＜0．01），용약전후상비차이균유통계학의의。결론미탁락이주사액치료심기교시유효적안전적，가이감경심기교대관맥적압박사협착정도감경。
Objective To inves tigate the effects of metoprolol on myocardial bridge , its clinical efficacy and safety were studied by using coronary angiography .Methods Based on coronary angiography , 72 patients with pure myocardial bridge were selected as study group .intravenous metoprolol injection 5 mg was given to them.10 min later, their blood pressure, heart rate and systolic myocardial bridge stenosis was measured again and compared with the result before the use of metoprolol .Results Metoprolol can reduce the stenosis of systolic myocardial bridge from 70.0% ±18.2% to 46.4% ±18.5% ( t =7.701, P<0.01);the heart rate from (75.5 ±7.0) to (65.3 ±6.8)beats /min(t=8.814, P<0.01); systolic blood pressure from (139 ±16) mmHg to (128 ±14) mmHg(t=4.280, P<0.01), and the diastolic blood pressure from the (75 ±8) mmHg to (66 ±4) mmHg (t=7.967, P<0.01).There were statistically significant differences .Conclusion metoprolol can reduce the stenosis of coronary artery caused by myocardial bridge and is effective and safe for the patients with myocardial bridge .