中国综合临床
中國綜閤臨床
중국종합림상
CLINICAL MEDICINE OF CHINA
2014年
9期
904-906
,共3页
刘君%高磊%刘凌%谭慧莲%郑庆厚%李跃征%王震%张密林
劉君%高磊%劉凌%譚慧蓮%鄭慶厚%李躍徵%王震%張密林
류군%고뢰%류릉%담혜련%정경후%리약정%왕진%장밀림
室间隔缺损%白细胞介素8%心功能%介入治疗
室間隔缺損%白細胞介素8%心功能%介入治療
실간격결손%백세포개소8%심공능%개입치료
Ventricular septal defect%Interleukin-8%Heart function%Interventional therapy
目的 观察先天性心脏病室间隔缺损(VSD)患儿介入治疗前后血浆白细胞介素8(IL-8)水平以及心腔结构的变化,探讨IL-8水平变化的特点及其与心功能状态的关系.方法 选择我院2011年2月至2013年2月住院接受介入封堵治疗的VSD患儿100例为VSD组,选取同期50名健康儿童作为对照组.分别在术前、术后第7天、术后6个月采用放射免疫法测定IL-8浓度.所有患儿在术前、术后第7天和术后6个月分别进行超声心动图检查,测定左心室舒张末期内径(LVEDD)、左心室收缩末期内径(LVESD)、左心室收缩末期容量(LVESV)、左心室舒张末期容量(LVEDV)、左心室射血分数(LVEF).分析血浆IL-8水平与LVEDD、LVESD、LVESV、LVEDV、LVEF的相关性.结果 (1)血浆IL-8:术前VSD组(0.64±0.08) pg/L和对照组(0.53 ±0.07) pg/L比较,差异有统计学意义(t=6.61,P＜0.05);VSD组患儿术前与术后第7天(0.69 ±0.06) pg/L、术后第7天与术后6个月(0.55±0.05)pg/L比较,差异均有统计学意义(t=5.45、t=12.08,P均＜0.05).术后6个月VSD组与对照组比较差异无统计学意义(t =0.86,P＞0.05).(2)心腔结构各参考数:VSD组患儿LVEDD、LVESD、LVEDV、LVESV在介入术后第7天[(41.47 ±3.38) mm、(27.17 ±3.76) mm、(76.72±17.03) ml、(26.23±6.13) ml]及术后6个月[(36.21±3.75) mm、(22.49 ±3.04) mm、(65.38±16.22) ml、(22.23±5.71) ml]均较术前[(45.28±3.69) mm、(29.02±3.17) mm、(86.33 ±19.68) ml、(30.12 ±7.06)nl]明显缩小,差异有统计学意义(P均＜0.05),且术后6个月较术后第7天进一步减小(P均＜0.05).(3)VSD组血浆IL-8水平与LVEDD、LVESD、LVESV、LVEDV呈显著正相关(r=0.76、0.59、0.66、0.75,P均＜0.05).结论 VSD患儿血浆IL-8水平在介入封堵术前明显增高,并在术后降低,且与心脏腔径的改善相关,提示心肌血管免疫炎症递质IL-8的过度激活参与并影响着VSD患儿心功能的变化.
目的 觀察先天性心髒病室間隔缺損(VSD)患兒介入治療前後血漿白細胞介素8(IL-8)水平以及心腔結構的變化,探討IL-8水平變化的特點及其與心功能狀態的關繫.方法 選擇我院2011年2月至2013年2月住院接受介入封堵治療的VSD患兒100例為VSD組,選取同期50名健康兒童作為對照組.分彆在術前、術後第7天、術後6箇月採用放射免疫法測定IL-8濃度.所有患兒在術前、術後第7天和術後6箇月分彆進行超聲心動圖檢查,測定左心室舒張末期內徑(LVEDD)、左心室收縮末期內徑(LVESD)、左心室收縮末期容量(LVESV)、左心室舒張末期容量(LVEDV)、左心室射血分數(LVEF).分析血漿IL-8水平與LVEDD、LVESD、LVESV、LVEDV、LVEF的相關性.結果 (1)血漿IL-8:術前VSD組(0.64±0.08) pg/L和對照組(0.53 ±0.07) pg/L比較,差異有統計學意義(t=6.61,P＜0.05);VSD組患兒術前與術後第7天(0.69 ±0.06) pg/L、術後第7天與術後6箇月(0.55±0.05)pg/L比較,差異均有統計學意義(t=5.45、t=12.08,P均＜0.05).術後6箇月VSD組與對照組比較差異無統計學意義(t =0.86,P＞0.05).(2)心腔結構各參攷數:VSD組患兒LVEDD、LVESD、LVEDV、LVESV在介入術後第7天[(41.47 ±3.38) mm、(27.17 ±3.76) mm、(76.72±17.03) ml、(26.23±6.13) ml]及術後6箇月[(36.21±3.75) mm、(22.49 ±3.04) mm、(65.38±16.22) ml、(22.23±5.71) ml]均較術前[(45.28±3.69) mm、(29.02±3.17) mm、(86.33 ±19.68) ml、(30.12 ±7.06)nl]明顯縮小,差異有統計學意義(P均＜0.05),且術後6箇月較術後第7天進一步減小(P均＜0.05).(3)VSD組血漿IL-8水平與LVEDD、LVESD、LVESV、LVEDV呈顯著正相關(r=0.76、0.59、0.66、0.75,P均＜0.05).結論 VSD患兒血漿IL-8水平在介入封堵術前明顯增高,併在術後降低,且與心髒腔徑的改善相關,提示心肌血管免疫炎癥遞質IL-8的過度激活參與併影響著VSD患兒心功能的變化.
목적 관찰선천성심장병실간격결손(VSD)환인개입치료전후혈장백세포개소8(IL-8)수평이급심강결구적변화,탐토IL-8수평변화적특점급기여심공능상태적관계.방법 선택아원2011년2월지2013년2월주원접수개입봉도치료적VSD환인100례위VSD조,선취동기50명건강인동작위대조조.분별재술전、술후제7천、술후6개월채용방사면역법측정IL-8농도.소유환인재술전、술후제7천화술후6개월분별진행초성심동도검사,측정좌심실서장말기내경(LVEDD)、좌심실수축말기내경(LVESD)、좌심실수축말기용량(LVESV)、좌심실서장말기용량(LVEDV)、좌심실사혈분수(LVEF).분석혈장IL-8수평여LVEDD、LVESD、LVESV、LVEDV、LVEF적상관성.결과 (1)혈장IL-8:술전VSD조(0.64±0.08) pg/L화대조조(0.53 ±0.07) pg/L비교,차이유통계학의의(t=6.61,P＜0.05);VSD조환인술전여술후제7천(0.69 ±0.06) pg/L、술후제7천여술후6개월(0.55±0.05)pg/L비교,차이균유통계학의의(t=5.45、t=12.08,P균＜0.05).술후6개월VSD조여대조조비교차이무통계학의의(t =0.86,P＞0.05).(2)심강결구각삼고수:VSD조환인LVEDD、LVESD、LVEDV、LVESV재개입술후제7천[(41.47 ±3.38) mm、(27.17 ±3.76) mm、(76.72±17.03) ml、(26.23±6.13) ml]급술후6개월[(36.21±3.75) mm、(22.49 ±3.04) mm、(65.38±16.22) ml、(22.23±5.71) ml]균교술전[(45.28±3.69) mm、(29.02±3.17) mm、(86.33 ±19.68) ml、(30.12 ±7.06)nl]명현축소,차이유통계학의의(P균＜0.05),차술후6개월교술후제7천진일보감소(P균＜0.05).(3)VSD조혈장IL-8수평여LVEDD、LVESD、LVESV、LVEDV정현저정상관(r=0.76、0.59、0.66、0.75,P균＜0.05).결론 VSD환인혈장IL-8수평재개입봉도술전명현증고,병재술후강저,차여심장강경적개선상관,제시심기혈관면역염증체질IL-8적과도격활삼여병영향착VSD환인심공능적변화.
Objective To observe the changes of plasma interleukin-8 (IL-8) and cardiac performance on children with ventricular septal defect (VSD) after interventional therapy in order to investigate the relationship between the cardiac performance and IL-8.Methods A total of 100 children with VSD for cardiac catheter occlusion in the 1 st Hospital of Hebei Medical University from Feb.2011 to Feb.2013 were enrolled in this study as the VSD group.The control group included 50 healthy children.Concentrations of plasma IL-8 were measured before and the 7th day and 6th month after cardiac catheterization.Before and the 7th day and 6th month after cardiac catheterization,the parameters of left ventricular end diastolic diameter (LVEDD),left ventricular end systolic diameter (LVESD),left ventricular end systolic volume (LVESV),left ventricular end diastolic volume (LVEDV) and left ventricular ejection fraction (LVEF) were measured by echocardiography.The relationships between plasma IL-8 levels and echocardiographic cardiac functional indexes were analyzed.Results (1) The plasma levels of IL-8 in VSD and control group were (0.64 ± 0.08) pg/L and (0.53 ±0.07) pg/L,and there was significant difference between two groups(t =6.61,P ＜ 0.05).IL-8 levels of VSD children at before operation,the 7th day and 6 month after operation were (0.64 ± 0.08) pg/L,(0.69 ± 0.06) pg/L,(0.55 ± 0.05) pg/L respectively,and the differences were statistically significant (t =5.45,t =12.08,P ＜0.05).There was no significant difference in terms of IL-8 at the 6 month after operation and before operation.(2) LVEDD,LVESD,LVEDV,LVESV in VSD children at the 7th days after operation were (41.47 ±3.38) mm,(27.17 ±3.76) mm,(76.72 ± 17.03) ml,(26.23 ±6.13) ml respectively,and (36.21 ± 3.75) mm,(22.49 ± 3.04) mm,(65.38 ± 16.22) ml,(22.23 ± 5.71) ml at the 6 months after operation,significant decreased than that before operation((45.28 ± 3.69) mm,(29.02 ± 3.17) mm,(86.33 ± 19.68)ml,(30.12 ± 7.06) ml; P ＜ 0.05).And the significant difference was seen in the 6th month after operation when compared with that at 7th day after operation(P ＜ 0.05).(3)There were significant positive correlation between level of plasma IL-8 and LVEDD,LVESV,LVESV,LVEDV (r =0.76,0.59,0.66,0.75 respectively; P ＜ 0.05) in VSD group.Conclusion The plasma IL-8 level increased significantly in VSD patients before transcatheter closure,and it reduces after operation which relate with the improvement of cardiac cavity size,suggesting myocardial vascular inflammatory mediators excessive activation of IL-8 participates in and affects the changes of cardiac function in children with VSD.
