中国神经精神疾病杂志
中國神經精神疾病雜誌
중국신경정신질병잡지
CHINESE JOURNAL OF NERVOUS AND MENTAL DISEASES
2014年
3期
138-142,148
,共6页
曹裕民%张雄%龙隆%万鑫%王硕%代成波%马桂贤%杨哲贤%马腾云%张玉虎%王丽娟
曹裕民%張雄%龍隆%萬鑫%王碩%代成波%馬桂賢%楊哲賢%馬騰雲%張玉虎%王麗娟
조유민%장웅%룡륭%만흠%왕석%대성파%마계현%양철현%마등운%장옥호%왕려연
血小板活化因子乙酰水解酶%基因多态性%脑动脉粥样硬化性狭窄%脑梗死%脑血管造影
血小闆活化因子乙酰水解酶%基因多態性%腦動脈粥樣硬化性狹窄%腦梗死%腦血管造影
혈소판활화인자을선수해매%기인다태성%뇌동맥죽양경화성협착%뇌경사%뇌혈관조영
Platelet-activating factor acetylhydrolase%Gene polymorphism%Cerebral artery atherosclerosis ste-nosis%Cerebral infarction%Cerebral digital subtraction angiography
目的：研究血小板活化因子乙酰水解酶（platelet-activating factor acetylhydrolase ，PAF-AH）基因Arg92His（4，275；G→A）、Ile198Thr（7，593；T→C）、Val279Phe（9，994；G→T）突变与脑动脉粥样硬化性狭窄（ce-rebral artery atherosclerotic stenosis，CAAS）及狭窄颅内外分布的关系。方法642例行全脑血管数字减影造影(cerebral digital subtraction angiography，DSA)检查的患者，根据狭窄程度，分为脑动脉狭窄（CAAS）组477例和对照组156例，CAAS组进一步分为3个亚组，单纯颅内动脉狭窄（intracranial atherosclerotic stenosis，ICAS）组，单纯颅外动脉狭窄（extracranial artery atherosclerotic stenosis ，ECAS）组，颅内外动脉联合狭窄（intracranial-extracranial artery atherosclerotic stenosis，IECAS）组。比较Arg92His、Ile198Thr、Val279Phe突变基因型及等位基因频率在各组的分布。结果 Arg92His突变基因型及等位基因频率，在ICAS组显著高于对照组（42.6%vs.30.3%；23.3%vs.16.4%）（P<0.05），而ECAS组、IECAS组突变基因型频率（28.7%，26.1%）及突变等位基因频率（17.0%，15.3%）与对照组比较，差异无统计学意义（P>0.05）。Ile198Thr、Val279Phe突变基因型及等位基因频率在ICAS组、ECAS组、IECAS组与对照组比较，差异均无统计学意义（P>0.05）。CAAS组与对照组比较，Arg92His、Ile198Thr、Val279Phe突变基因型及等位基因频率差异无统计学意义（P>0.05）。结论Arg92His位点突变可能参与了颅内动脉粥样硬化性狭窄的发生。
目的：研究血小闆活化因子乙酰水解酶（platelet-activating factor acetylhydrolase ，PAF-AH）基因Arg92His（4，275；G→A）、Ile198Thr（7，593；T→C）、Val279Phe（9，994；G→T）突變與腦動脈粥樣硬化性狹窄（ce-rebral artery atherosclerotic stenosis，CAAS）及狹窄顱內外分佈的關繫。方法642例行全腦血管數字減影造影(cerebral digital subtraction angiography，DSA)檢查的患者，根據狹窄程度，分為腦動脈狹窄（CAAS）組477例和對照組156例，CAAS組進一步分為3箇亞組，單純顱內動脈狹窄（intracranial atherosclerotic stenosis，ICAS）組，單純顱外動脈狹窄（extracranial artery atherosclerotic stenosis ，ECAS）組，顱內外動脈聯閤狹窄（intracranial-extracranial artery atherosclerotic stenosis，IECAS）組。比較Arg92His、Ile198Thr、Val279Phe突變基因型及等位基因頻率在各組的分佈。結果 Arg92His突變基因型及等位基因頻率，在ICAS組顯著高于對照組（42.6%vs.30.3%；23.3%vs.16.4%）（P<0.05），而ECAS組、IECAS組突變基因型頻率（28.7%，26.1%）及突變等位基因頻率（17.0%，15.3%）與對照組比較，差異無統計學意義（P>0.05）。Ile198Thr、Val279Phe突變基因型及等位基因頻率在ICAS組、ECAS組、IECAS組與對照組比較，差異均無統計學意義（P>0.05）。CAAS組與對照組比較，Arg92His、Ile198Thr、Val279Phe突變基因型及等位基因頻率差異無統計學意義（P>0.05）。結論Arg92His位點突變可能參與瞭顱內動脈粥樣硬化性狹窄的髮生。
목적：연구혈소판활화인자을선수해매（platelet-activating factor acetylhydrolase ，PAF-AH）기인Arg92His（4，275；G→A）、Ile198Thr（7，593；T→C）、Val279Phe（9，994；G→T）돌변여뇌동맥죽양경화성협착（ce-rebral artery atherosclerotic stenosis，CAAS）급협착로내외분포적관계。방법642례행전뇌혈관수자감영조영(cerebral digital subtraction angiography，DSA)검사적환자，근거협착정도，분위뇌동맥협착（CAAS）조477례화대조조156례，CAAS조진일보분위3개아조，단순로내동맥협착（intracranial atherosclerotic stenosis，ICAS）조，단순로외동맥협착（extracranial artery atherosclerotic stenosis ，ECAS）조，로내외동맥연합협착（intracranial-extracranial artery atherosclerotic stenosis，IECAS）조。비교Arg92His、Ile198Thr、Val279Phe돌변기인형급등위기인빈솔재각조적분포。결과 Arg92His돌변기인형급등위기인빈솔，재ICAS조현저고우대조조（42.6%vs.30.3%；23.3%vs.16.4%）（P<0.05），이ECAS조、IECAS조돌변기인형빈솔（28.7%，26.1%）급돌변등위기인빈솔（17.0%，15.3%）여대조조비교，차이무통계학의의（P>0.05）。Ile198Thr、Val279Phe돌변기인형급등위기인빈솔재ICAS조、ECAS조、IECAS조여대조조비교，차이균무통계학의의（P>0.05）。CAAS조여대조조비교，Arg92His、Ile198Thr、Val279Phe돌변기인형급등위기인빈솔차이무통계학의의（P>0.05）。결론Arg92His위점돌변가능삼여료로내동맥죽양경화성협착적발생。
Objective To investigate the relationship between platelet-activating factor acetylhydrolase gene Arg92His(4, 275; G→A), Ile198Thr(7, 593; T→C) and Val279Phe(9, 994; G→T) mutation and cerebral artery athero-sclerosis stenosis. Methods Six hundred forty-twopatients with cerebral infarction underwent cerebral digital subtrac-tion angiography (DSA).The patients were then divided into cerebral artery atherosclerosis stenosis (CAAS) group(n=477) and control group(n=81) accroding to the site and severity of their cerebral artery stenosis. Furthermore, the CAAS group were divided into intracranial artery stenosis(ICAS) subgroup(n=251), extracranial artery stenosis(ECAS) subgroup (n=115) and extracranial-intracerebral artery stenosis(ECAS) subgroup(n=111). The distributions of genotype and allele frequencies of Arg92His,Ile198Thr and Val279Phe mutation of platelet-activating factor acetylhydrolase gene were ex-amined and comparied in different groups. Results There were significant differences in the distributions of genotype and allele of Arg92His mutation between ICAS subgroup and control group(42.6% vs. 30.3%;23.3% vs. 16.4%, P <0.05). These associations were not detected in ECAS and IECAS subgroups. There was no significant association be-tween Ile198Thr and Val279Phe and stenosis at any site(P>0.05). The distributions of genotype and allele of Arg92His, Ile198Thr and Val279Phe mutation were no significantly difference between CAAS group and control group (P >0.05). Conclusions Arg92His mutation may be associated with intracranial artery atherosclerotic stenosis.
