新疆医学
新疆醫學
신강의학
XINJIANG MEDICAL JOURNAL
2014年
4期
12-16
,共5页
COPD%谷胱甘肽%白介素18
COPD%穀胱甘肽%白介素18
COPD%곡광감태%백개소18
COPD%GSH%IL-18
目的：通过对慢性阻塞性肺疾病（Chronic Obstructive Pulmonary Disease，COPD）患者与正常人血清谷胱甘肽（glutathione，GSH）和白介素18（IL-18）的表达检测，探讨其在COPD中的作用。方法：采集32例COPD患者、30例正常人血清，测第一秒用力呼气容积/用力肺活量（FEV1.0/FVC%）提示肺功能，通过比色法和酶联免疫吸附法测定不同阶段血清中GSH和IL-18水平。结果：COPD稳定期较急性期肺功能显著提高（P＜0.05），GSH水平明显升高（P＜0.05），IL-18水平显著降低（P＜0.05）；正常组较COPD组有显著差异（P＜0.05）。结论：随着COPD患者的转归，GSH血清水平增高而IL-18水平降低，提示GSH可能是COPD的保护性因素，而高水平的IL-18与COPD发病相关。
目的：通過對慢性阻塞性肺疾病（Chronic Obstructive Pulmonary Disease，COPD）患者與正常人血清穀胱甘肽（glutathione，GSH）和白介素18（IL-18）的錶達檢測，探討其在COPD中的作用。方法：採集32例COPD患者、30例正常人血清，測第一秒用力呼氣容積/用力肺活量（FEV1.0/FVC%）提示肺功能，通過比色法和酶聯免疫吸附法測定不同階段血清中GSH和IL-18水平。結果：COPD穩定期較急性期肺功能顯著提高（P＜0.05），GSH水平明顯升高（P＜0.05），IL-18水平顯著降低（P＜0.05）；正常組較COPD組有顯著差異（P＜0.05）。結論：隨著COPD患者的轉歸，GSH血清水平增高而IL-18水平降低，提示GSH可能是COPD的保護性因素，而高水平的IL-18與COPD髮病相關。
목적：통과대만성조새성폐질병（Chronic Obstructive Pulmonary Disease，COPD）환자여정상인혈청곡광감태（glutathione，GSH）화백개소18（IL-18）적표체검측，탐토기재COPD중적작용。방법：채집32례COPD환자、30례정상인혈청，측제일초용력호기용적/용력폐활량（FEV1.0/FVC%）제시폐공능，통과비색법화매련면역흡부법측정불동계단혈청중GSH화IL-18수평。결과：COPD은정기교급성기폐공능현저제고（P＜0.05），GSH수평명현승고（P＜0.05），IL-18수평현저강저（P＜0.05）；정상조교COPD조유현저차이（P＜0.05）。결론：수착COPD환자적전귀，GSH혈청수평증고이IL-18수평강저，제시GSH가능시COPD적보호성인소，이고수평적IL-18여COPD발병상관。
Objective:To discuss the function of difference expression of GSH (glutathione, GSH) and IL-18 in patients of COPD. Methods: Collect the serum of 32 COPD patients and 30 normal people. According the FEV1.0 (forced expiratory volume in one second,FEV1.0) and FEV1.0/FVC (forced vital capacity rate of one second) to detect the lung function of COPD patients. The colorimetric method and the enzyme-linked immunosorbent assay (ELISA) method were used to detect the level of GSH and IL-18 in serum of the different stage of COPD and normal person. Then we analyzed the difference in different groups. Results: Acute stage COPD patients were transfered to stable stage after drug treatment. Lung function indices (FEV1.0 and FEV1.0/FVC) and GSH level improved apparently in stable stage patients (p<0.05) while the level of IL-18 was significantly reduced in stable stage (p<0.05). These indexes have significantly difference in COPD patients and normal control. GSH level in normal control people was also high while IL-18 was low. GSH and IL-18 in different group have no relevance (p>0.05). Conclusion:With the improvement of the symptoms of COPD patients, GSH level in serum was increased while IL-18 was decreased. That means GSH is a protective factor for COPD patients, while high level IL-18 was related with morbidity of COPD.
