军事医学
軍事醫學
군사의학
BULLETIN OF THE ACADEMY OF MILITARY MEDICAL SCIENCES
2014年
4期
252-254,258
,共4页
杨特%武晓静%李双菲%李相俊%覃军%黄岚
楊特%武曉靜%李雙菲%李相俊%覃軍%黃嵐
양특%무효정%리쌍비%리상준%담군%황람
高原%肺动脉高压%右心功能%体能
高原%肺動脈高壓%右心功能%體能
고원%폐동맥고압%우심공능%체능
high altitude%pulmonary hypertension%right heart function%exercise capacity
目的:探讨急性高原暴露时肺动脉压变化对体能的影响及机制。方法2012年7~8月,以231名健康男性青年为研究对象,根据高原暴露情况分为平原组(n=135)、急进高原组(n=96),观察平均肺动脉压(MPAP)变化对体能( PWC170)的影响并分析生命体征、心功能指标变化在其中的作用。结果①急进高原组MPAP、右心室(RV)-Tei指数较平原组显著升高[MPAP:(23.07±6.85)mmHg vs (14.93±3.88)mmHg,P<0.01;RV-Tei:0.27±0.06 vs 0.19±0.05,P<0.01],PWC170较平原组显著降低[(807.86±133.22) kg· m/min vs (1003.33±168.11)kg· m/min,P<0.01];②急性高原暴露后肺动脉压增高组PWC170显著低于肺动脉压正常组[(726.97±102.47)kg· m/min vs (846.43±129.39)kg· m/min,P<0.01],RV-Tei显著高于肺动脉压正常组(0.31±0.07 vs 0.25±0.05, P<0.01)。 PWC170与 MPAP 呈负相关:R =-0.41, P <0.01;PWC170与 RV-Tei 呈负相关:R=-0.30,P<0.01。结论急性高原暴露时肺动脉压增高是体能下降的重要原因之一,其机制可能与肺动脉压增高导致右心功能降低有关。
目的:探討急性高原暴露時肺動脈壓變化對體能的影響及機製。方法2012年7~8月,以231名健康男性青年為研究對象,根據高原暴露情況分為平原組(n=135)、急進高原組(n=96),觀察平均肺動脈壓(MPAP)變化對體能( PWC170)的影響併分析生命體徵、心功能指標變化在其中的作用。結果①急進高原組MPAP、右心室(RV)-Tei指數較平原組顯著升高[MPAP:(23.07±6.85)mmHg vs (14.93±3.88)mmHg,P<0.01;RV-Tei:0.27±0.06 vs 0.19±0.05,P<0.01],PWC170較平原組顯著降低[(807.86±133.22) kg· m/min vs (1003.33±168.11)kg· m/min,P<0.01];②急性高原暴露後肺動脈壓增高組PWC170顯著低于肺動脈壓正常組[(726.97±102.47)kg· m/min vs (846.43±129.39)kg· m/min,P<0.01],RV-Tei顯著高于肺動脈壓正常組(0.31±0.07 vs 0.25±0.05, P<0.01)。 PWC170與 MPAP 呈負相關:R =-0.41, P <0.01;PWC170與 RV-Tei 呈負相關:R=-0.30,P<0.01。結論急性高原暴露時肺動脈壓增高是體能下降的重要原因之一,其機製可能與肺動脈壓增高導緻右心功能降低有關。
목적:탐토급성고원폭로시폐동맥압변화대체능적영향급궤제。방법2012년7~8월,이231명건강남성청년위연구대상,근거고원폭로정황분위평원조(n=135)、급진고원조(n=96),관찰평균폐동맥압(MPAP)변화대체능( PWC170)적영향병분석생명체정、심공능지표변화재기중적작용。결과①급진고원조MPAP、우심실(RV)-Tei지수교평원조현저승고[MPAP:(23.07±6.85)mmHg vs (14.93±3.88)mmHg,P<0.01;RV-Tei:0.27±0.06 vs 0.19±0.05,P<0.01],PWC170교평원조현저강저[(807.86±133.22) kg· m/min vs (1003.33±168.11)kg· m/min,P<0.01];②급성고원폭로후폐동맥압증고조PWC170현저저우폐동맥압정상조[(726.97±102.47)kg· m/min vs (846.43±129.39)kg· m/min,P<0.01],RV-Tei현저고우폐동맥압정상조(0.31±0.07 vs 0.25±0.05, P<0.01)。 PWC170여 MPAP 정부상관:R =-0.41, P <0.01;PWC170여 RV-Tei 정부상관:R=-0.30,P<0.01。결론급성고원폭로시폐동맥압증고시체능하강적중요원인지일,기궤제가능여폐동맥압증고도치우심공능강저유관。
Objective To investigate the effect and mechanism of pulmonary artery pressure on exercise capacity after acute high altitude exposure .Methods A total of 231 persons were recruited in this study , whose vital signs,SaO2 and physical working capacity ( PWC170 ) exercise capacity were collected .The difference between groups with normal and increased MPAP was observed .Results mean pulmonary artery pressure ( MPAP ) and right ventricle ( RV )-Tei index increased substantially after acute high altitude exposure ,while PWC170 was remarkably decreased .Furthermore,it was found that those whose MPAP increased(MPAP≥25 mmHg)had higher RV-Tei and lower PWC170(P<0.01) in acute high altitude exposure group .Correlation analysis suggested that there were different levels of correlation between MPAP, RV-Tei and PWC170(P<0.01).Conclusion After acute high altitude exposure , the increased pulmonary artery pressure is one of the main causes of lowered exercise capacity .The mechanism may be associated with the decrease of right heart functions .