CAJ | 학술논문

目的：探讨高原暴露对肺功能的影响及肺功能与急性高原病（ acute mountain sickness ，AMS）间的关系。方法采集了73人（18～26岁，男）平原（400 m，上高原前7 d）及高原（3900 m，暴露5 d）的肺功能和路易斯湖评分数据。结果自身前后对照t检验分析显示：与平原相比，高原的肺功能用力肺活量（ FVC）、最大呼气中期流速（MMF）、V50、V20下降，而1 s用力呼气容积（FEV1）、峰值呼气流速（PEF）、V75没有变化；选取了FVC 、FEV1、PEF、MMF这3个指标分析肺功能与AMS的关系，AMS组与NON-AMS组相比，平原的肺功能没有差异，高原的肺功能FVC、MMF具有统计学差异；变化幅度在FVC、MMF上有差异；Logistic回归分析显示FVC的变化幅度是独立的危险因素，相关分析显示FVC的变化和氧饱和度的变化具有相关性。结论急性高原暴露使肺通气功能呈现限制性下降，肺功能的这种变化会加重低氧而易感AMS。
목적：탐토고원폭로대폐공능적영향급폐공능여급성고원병（ acute mountain sickness ，AMS）간적관계。방법채집료73인（18～26세，남）평원（400 m，상고원전7 d）급고원（3900 m，폭로5 d）적폐공능화로역사호평분수거。결과자신전후대조t검험분석현시：여평원상비，고원적폐공능용력폐활량（ FVC）、최대호기중기류속（MMF）、V50、V20하강，이1 s용력호기용적（FEV1）、봉치호기류속（PEF）、V75몰유변화；선취료FVC 、FEV1、PEF、MMF저3개지표분석폐공능여AMS적관계，AMS조여NON-AMS조상비，평원적폐공능몰유차이，고원적폐공능FVC、MMF구유통계학차이；변화폭도재FVC、MMF상유차이；Logistic회귀분석현시FVC적변화폭도시독립적위험인소，상관분석현시FVC적변화화양포화도적변화구유상관성。결론급성고원폭로사폐통기공능정현한제성하강，폐공능적저충변화회가중저양이역감AMS。
Objective To investigate the effect of acute high altitude exposure on lung functions and the relationship between lung functions and acute mountain sickness ( AMS) .Method We collected the lung function and Lewis Lake data of 73 subjects (aged 18 to 26,male) at 400 m above sea-leve and those at high altitude(exposure to 3900 m, 5 d).Results Compared with sea-level, lung functions decreased in forced vital capucity (FVC), maximum midexpiratory flow(MMF), V50, V25 while forced expiratory volume in 1 second(FEV1), peak expiratory flow(PEF), V75 did not change.FVC, FEV1, PEF, MMF were used to analyze the relationship between lung functions and AMS .There was no difference in lung functions between AMS group and NON AMS group at sea-level, but lung functions of AMS group were significantly lower than those of NON AMS group in FVC , MMF at high altitude .There was difference between AMS group and NON AMS group in the rate of change of FVC and MMF .Logistic regression analysis showed that the rate of change of FVC was an independent risk factor , while correlation analysis showed that the change of FVC and the change of oxygen saturation were relevant.Conclusion Lung functions showed restrictive decrease after acute high altitude exposure .Changes of lung func-tions will increase hypoxia and susceptiblity to AMS .