CAJ | 학술논문

目的探讨慢性乙型肝炎病毒感染者血清乙肝表面抗原定量水平与肝脏病理之间的关系.方法收集我院272例乙肝表面抗原阳性超过6个月并接受肝脏穿刺活检的患者的临床资料.检测血清乙肝表面抗原定量、乙肝病毒基因型、ALT、HBV DNA、血常规、肝脏组织病理等各项资料,分别按照肝脏炎症活动程度(G0、G1、G2、G3、G4)和纤维化程度(S0、S1、S2、S3、S4)分组.观察分析乙肝表面抗原定量、HBV DNA与肝组织炎症活动程度和纤维化程度之间的关系.分析乙肝表面抗原定量与HBV DNA之间的相关性.结果乙肝表面抗原定量与HBV DNA之间的相关性是显著的,表面抗原定量对数是对肝脏纤维化有显著影响的变量.结论乙肝表面抗原对数是较DNA定量对数特异度和灵敏度更高的诊断肝脏纤维化程度的指标.
목적 탐토만성을형간염병독감염자혈청을간표면항원정량수평여간장병리지간적관계.방법 수집아원272례을간표면항원양성초과6개월병접수간장천자활검적환자적림상자료.검측혈청을간표면항원정량、을간병독기인형、ALT、HBV DNA、혈상규、간장조직병리등각항자료,분별안조간장염증활동정도(G0、G1、G2、G3、G4)화섬유화정도(S0、S1、S2、S3、S4)분조.관찰분석을간표면항원정량、HBV DNA여간조직염증활동정도화섬유화정도지간적관계.분석을간표면항원정량여HBV DNA지간적상관성.결과 을간표면항원정량여HBV DNA지간적상관성시현저적,표면항원정량대수시대간장섬유화유현저영향적변량.결론 을간표면항원대수시교DNA정량대수특이도화령민도경고적진단간장섬유화정도적지표.
Objective To explore the correlation of serum hepatitis B surface antigen (HBsAg)level and hepatic tissue pathological staging in the chronic hepatitis B infected persons.Methods Collect the clinical data of 272 cases who are HBsAg-positive more than 6 months and accepted hepatic biopsy in our hospital.Detect serum HBsAg quantification,ALT,HBV DNA,complete blood count,hepatic tissue pathological staging,grouping the cases according to the stage of inflammation and the fibrosis degree respectively.Observe serum HBsAg quantification,HBV DNA and the stage of inflammation and the fibrosis degree.Analyse the correlation between HBsAg quantification and HBV DNA.Results The correlation of serum HBsAg level and HBV DNA is notable.Serum HBsAg level is a variable affecting hepatic tissue pathological stage significantly.Conclusions Serum HBsAg level is a marker having higher specificity and sensitivity to diagnose the hepatic fibrosis.