CAJ | 학술논문

探讨新型立式网状宫内节育器（new three-dimensional and reticular intrauterine device，NTDR-IUD）对正常子宫肌电和内膜容受性的影响。制作3种规格（短、中及长）的IUD，放置在成年雌性新西兰大白兔子宫内，按常规无菌手术在耻骨联合正中切口切开腹壁，应用电生理仪进行子宫肌电检测。放置NTDR-IUD后，慢波频率加快，平均振幅增大，单波最大振幅增大，频率加快；短、中及长NTDR-IUD使兔子宫肌电爆发波的持续时间逐渐延长，最大振幅增大；10只正常对照组合笼1月后均妊娠，短NTDR-IUD组有5只在未被IUD占据的部位发现兔胎，中NTDR-IUD组有2只发现兔胎，长NTDR-IUD组未发现兔胎。妊娠只数长NTDR-IUD组与对照组比较，差异有统计学意义（P=0.000）；短NTDR-IUD组与对照组及长NTDR-IUD组比较，均有统计学意义（P=0.033），中等长度NTDR-IUD组与对照组比较，有统计学意义（P=0.001）。NTDR-IUD通过干扰子宫肌电参与避孕，其避孕效果与IUD大小有关。
탐토신형입식망상궁내절육기（new three-dimensional and reticular intrauterine device，NTDR-IUD）대정상자궁기전화내막용수성적영향。제작3충규격（단、중급장）적IUD，방치재성년자성신서란대백토자궁내，안상규무균수술재치골연합정중절구절개복벽，응용전생리의진행자궁기전검측。방치NTDR-IUD후，만파빈솔가쾌，평균진폭증대，단파최대진폭증대，빈솔가쾌；단、중급장NTDR-IUD사토자궁기전폭발파적지속시간축점연장，최대진폭증대；10지정상대조조합롱1월후균임신，단NTDR-IUD조유5지재미피IUD점거적부위발현토태，중NTDR-IUD조유2지발현토태，장NTDR-IUD조미발현토태。임신지수장NTDR-IUD조여대조조비교，차이유통계학의의（P=0.000）；단NTDR-IUD조여대조조급장NTDR-IUD조비교，균유통계학의의（P=0.033），중등장도NTDR-IUD조여대조조비교，유통계학의의（P=0.001）。NTDR-IUD통과간우자궁기전삼여피잉，기피잉효과여IUD대소유관。
This study is to explore the influence of new three-dimensional and reticular intra-uterine device (NTDR-IUD) on animal uterine electromyography and endometrial receptivity as the goal. Three types (short,median and long) of NTDR-IUD were placed into uterus of female white New Zealand rabbits. Conventional surgical incision was performed in the abdominal wall of rabbits,the uterine electromyography (EMG) was carried out by muscular electrophysi-ological testing. After placing NTDR-IUD,the slow wave frequency and average amplitude were increased. All of rabbits of control group were pregnant,and 5 pregnancies (fetal rabbits were found in the uterus without NTDR-IUD portion) in short group and 2 in median group. No pregnancy was found in the long NTDR-IUD group. The number of pregnant rabbits was signifi-cant difference between control group and the short ,median and long of NTDR-IUD group (P=0.000,P=0.033 and P=0.001). The contraceptive effect of NTDR-IUD may be by interfer-ing with uterine EMG,and related with its size and shape.