CAJ | 학술논문

免疫是机体的基本防御屏障，与乳腺癌的发生、发展、治疗及预后密切相关。辅助放疗是乳腺癌综合治疗的重要组成部分。传统观点认为放疗可直接破坏机体免疫细胞，进而抑制机体免疫的抗肿瘤效果。而近期研究表明，放疗可刺激免疫系统产生一系列积极反应，有利于肿瘤杀伤过程中抗原的加工、提呈、识别及肿瘤的最终杀伤。临床方面，放疗联合多种免疫靶向治疗相继进入临床试验阶段。本文将对乳腺癌放疗对抗肿瘤免疫影响的研究发展及现状进行介绍。
면역시궤체적기본방어병장，여유선암적발생、발전、치료급예후밀절상관。보조방료시유선암종합치료적중요조성부분。전통관점인위방료가직접파배궤체면역세포，진이억제궤체면역적항종류효과。이근기연구표명，방료가자격면역계통산생일계렬적겁반응，유리우종류살상과정중항원적가공、제정、식별급종류적최종살상。림상방면，방료연합다충면역파향치료상계진입림상시험계단。본문장대유선암방료대항종류면역영향적연구발전급현상진행개소。
Immunity is the basic defense barrier for body, and also closely related to the development, progression, treatment and prognosis of breast cancer. Adjuvant radiotherapy plays an important role in the multidisciplinary treatment of breast cancer. It has long been believed that radiotherapy was immunosuppressive because it could destroy the body’s immune cells directly. While recent studies have shown that radiotherapy can stimulate the host immune system in the antitumor process, including antigen processing, presentation, recognition, and eventually tumor-cell killing. In the clinical aspect, a variety of immune targeted therapies, combined with radiotherapy, have entered clinical trials. The article reviewed research progress and status of the inlfuence of breast cancer adjuvant radiotherapy on antitumor immunity.