CAJ | 학술논문

用冻干显微镜和差示扫描量热仪测定了氯化钠盐溶液、蔗糖水溶液、海藻糖水溶液和甘露醇水溶液的塌陷温度和玻璃化转变温度，研究两者之间的关系。实验表明，塌陷温度一般都比相应的玻璃化转变温度高5℃左右；质量浓度越大，降温速率越小，则塌陷温度越大；不同物质，分子量越大，则塌陷温度越大。塌陷温度是在真正的冷冻干燥过程中测得的，更能真实反映产品的特性，较玻璃化转变温度和共晶熔融温度对冷冻干燥更具指导意义。所以，以塌陷温度作为临界温度，可以提高升华干燥速率，缩短冻干时间。
용동간현미경화차시소묘량열의측정료록화납염용액、자당수용액、해조당수용액화감로순수용액적탑함온도화파리화전변온도，연구량자지간적관계。실험표명，탑함온도일반도비상응적파리화전변온도고5℃좌우；질량농도월대，강온속솔월소，칙탑함온도월대；불동물질，분자량월대，칙탑함온도월대。탑함온도시재진정적냉동간조과정중측득적，경능진실반영산품적특성，교파리화전변온도화공정용융온도대냉동간조경구지도의의。소이，이탑함온도작위림계온도，가이제고승화간조속솔，축단동간시간。
The relationship between collapse temperature and glass transition temperature of sodium chlo-ride,sucrose,trehalose and mannitol solutions was investigated using freeze-drying microscope(FDM)and differential scanning calorimeter( DSC). Experiments found that the collapse temperature is generally 5 ℃ higher than the glass transition temperature. The higher mass concentration and the slower the cool-ing rate were,the higher collapse temperature was. As to different substances,the higher the molecular weight was,the higher collapse temperature was. Collapse temperature was measured in the process of freeze-drying,so it was closer to the actual freeze-drying process,and therefore it is more guiding signifi-cance than the glass transition temperature and eutectic melting temperature for freeze-drying. Thus col-lapse temperature can be the critical temperature of sublimation,by which it can accelerate the freeze-dr-ying process and save time.