中华临床医师杂志(电子版)
中華臨床醫師雜誌(電子版)
중화림상의사잡지(전자판)
CHINESE JOURNAL OF CLINICIANS(ELECTRONIC VERSION)
2014年
9期
1743-1747
,共5页
脓毒症%C反应蛋白质%可溶性白细胞分化抗原-14%降钙素原%白细胞介素6
膿毒癥%C反應蛋白質%可溶性白細胞分化抗原-14%降鈣素原%白細胞介素6
농독증%C반응단백질%가용성백세포분화항원-14%강개소원%백세포개소6
Sepsis%C-reactive protein%sCD14-st%Procalcitonin%Interleukin-6
脓毒症、严重脓毒症和脓毒症休克是急诊科经常处理的疾病,有很高的病死率,早期诊断是提高生存率的关键因素之一。近几年,降钙素原被用作诊断脓毒症患者的生物学标记物,尽管它与感染密切相关,但是特异性有限,在发生全身炎症反应综合征时会升高。可溶性白细胞分化抗原14(sCD14-st,又称presepsin)是一种存在于单核细胞/巨噬细胞中的糖蛋白。初步报道显示脓毒症患者体内的sCD14-st水平比健康者体内的sCD14-st显著升高。
膿毒癥、嚴重膿毒癥和膿毒癥休剋是急診科經常處理的疾病,有很高的病死率,早期診斷是提高生存率的關鍵因素之一。近幾年,降鈣素原被用作診斷膿毒癥患者的生物學標記物,儘管它與感染密切相關,但是特異性有限,在髮生全身炎癥反應綜閤徵時會升高。可溶性白細胞分化抗原14(sCD14-st,又稱presepsin)是一種存在于單覈細胞/巨噬細胞中的糖蛋白。初步報道顯示膿毒癥患者體內的sCD14-st水平比健康者體內的sCD14-st顯著升高。
농독증、엄중농독증화농독증휴극시급진과경상처리적질병,유흔고적병사솔,조기진단시제고생존솔적관건인소지일。근궤년,강개소원피용작진단농독증환자적생물학표기물,진관타여감염밀절상관,단시특이성유한,재발생전신염증반응종합정시회승고。가용성백세포분화항원14(sCD14-st,우칭presepsin)시일충존재우단핵세포/거서세포중적당단백。초보보도현시농독증환자체내적sCD14-st수평비건강자체내적sCD14-st현저승고。
Sepsis, severe sepsis and septic shock are frequent conditions with high mortality, their early diagnosis in the emergency department is one of the keys to improve survival. Procalcitonin (PCT) has been used as a biomarker in septic patients and although it closely correlates with infections, it has limited specificity, and can be elevated in other scenarios of systemic inflammatory response syndrome (SIRS). Soluble CD14 (or Presepsin) is the free fragment of a glycoprotein expressed on monocytes/macrophages. Preliminary reports suggest that levels of soluble CD14 are significantly higher in septic patients compared to healthy individuals.