中华临床医师杂志（电子版）
中華臨床醫師雜誌（電子版）
중화림상의사잡지（전자판）
CHINESE JOURNAL OF CLINICIANS(ELECTRONIC VERSION)
2014年
9期
1606-1609
,共4页
鹿慧%王斌全%李建民%张婕
鹿慧%王斌全%李建民%張婕
록혜%왕빈전%리건민%장첩
肿瘤,鳞状细胞%程序性细胞死亡因子4%免疫组织化学%周期蛋白依赖激酶抑制因子1A/p21
腫瘤,鱗狀細胞%程序性細胞死亡因子4%免疫組織化學%週期蛋白依賴激酶抑製因子1A/p21
종류,린상세포%정서성세포사망인자4%면역조직화학%주기단백의뢰격매억제인자1A/p21
Neoplasms,squamous cell%Programmed cell death protein 4%Immunohistochermistry%Cyclin-dependent kinase inhibitor 1A/p21
目的：探讨PDCD4、CDKN1A/p21在喉鳞状细胞癌组织中的表达与相关病理参数间的关系及二者间的相关性。方法使用免疫组化法检测PDCD4及CDKN1A/p21蛋白在喉鳞癌及癌旁正常组织中的表达，结合患者性别、年龄、病理分期、淋巴结转移等情况进行χ2检验及Spearman秩相关检验。结果 PDCD4在喉鳞癌组织中阳性表达率为40.30%，癌旁正常组织中阳性表达率58.21%，差异有统计学意义（P＜0.05）；CDKN1A/p21在喉鳞癌组织中阳性表达率为37.31%，癌旁正常组织中阳性表达率55.22%，差异有统计学意义（P＜0.05）。喉鳞状细胞癌中PDCD4表达下调，与喉鳞癌分化程度、T 分期相关（P＜0.05）；CDKN1A/p21表达下调，与喉鳞癌分化程度及淋巴转移相关（P＜0.05）。PDCD4与CDKN1A/p21二者正相关（r＝0.478，P＝0.000）。结论 PDCD4与CDKN1A/p21与喉鳞癌发生及恶性发展密切相关，可作为喉鳞癌病理诊断、治疗和预后判断的一项指标。
目的：探討PDCD4、CDKN1A/p21在喉鱗狀細胞癌組織中的錶達與相關病理參數間的關繫及二者間的相關性。方法使用免疫組化法檢測PDCD4及CDKN1A/p21蛋白在喉鱗癌及癌徬正常組織中的錶達，結閤患者性彆、年齡、病理分期、淋巴結轉移等情況進行χ2檢驗及Spearman秩相關檢驗。結果 PDCD4在喉鱗癌組織中暘性錶達率為40.30%，癌徬正常組織中暘性錶達率58.21%，差異有統計學意義（P＜0.05）；CDKN1A/p21在喉鱗癌組織中暘性錶達率為37.31%，癌徬正常組織中暘性錶達率55.22%，差異有統計學意義（P＜0.05）。喉鱗狀細胞癌中PDCD4錶達下調，與喉鱗癌分化程度、T 分期相關（P＜0.05）；CDKN1A/p21錶達下調，與喉鱗癌分化程度及淋巴轉移相關（P＜0.05）。PDCD4與CDKN1A/p21二者正相關（r＝0.478，P＝0.000）。結論 PDCD4與CDKN1A/p21與喉鱗癌髮生及噁性髮展密切相關，可作為喉鱗癌病理診斷、治療和預後判斷的一項指標。
목적：탐토PDCD4、CDKN1A/p21재후린상세포암조직중적표체여상관병리삼수간적관계급이자간적상관성。방법사용면역조화법검측PDCD4급CDKN1A/p21단백재후린암급암방정상조직중적표체，결합환자성별、년령、병리분기、림파결전이등정황진행χ2검험급Spearman질상관검험。결과 PDCD4재후린암조직중양성표체솔위40.30%，암방정상조직중양성표체솔58.21%，차이유통계학의의（P＜0.05）；CDKN1A/p21재후린암조직중양성표체솔위37.31%，암방정상조직중양성표체솔55.22%，차이유통계학의의（P＜0.05）。후린상세포암중PDCD4표체하조，여후린암분화정도、T 분기상관（P＜0.05）；CDKN1A/p21표체하조，여후린암분화정도급림파전이상관（P＜0.05）。PDCD4여CDKN1A/p21이자정상관（r＝0.478，P＝0.000）。결론 PDCD4여CDKN1A/p21여후린암발생급악성발전밀절상관，가작위후린암병리진단、치료화예후판단적일항지표。
Objective To explore the relationship between PDCD4, CDKN1A/p21 expression in laryngeal squamous cell carcinoma(LSCC) and the related pathological parameters. The correlation between them is also studied. Methods Protein levels of PDCD4 and CDKN1A/p21 in laryngeal squamous cell carcinoma and normal tissues were determined by immunohistochemistry. Chi-square test and Spearman rank correlation test were conducted by the combination of the patient sex, age, pathologic stage and the lymph node metastasis. Results The results showed that the expression rate of PDCD4 in laryngeal squamous cell carcinoma was 40.30%, but in the normal tissues was 58.21%. There had significant difference between these two groups(P<0.05). Similarly, remarkable difference was also found in CDKN1A/p21 expression between laryngeal squamous cell carcinoma and normal tissues(P<0.05), the expression rate was 37.31% and 55.22% respectively. Furthermore, the downregulation of PDCD4 in laryngeal squamous cell carcinoma was correlated with laryngeal squamous differentiation degree and T staging(P<0.05), while CDKN1A/p21 was associated with laryngeal squamous cell carcinoma differentiation and lymphatic metastasis(P<0.05). PDCD4 was positively correlated with CDKN1A/p21 (r=0.478, P=0.000). Conclusion PDCD4 and CDKN1A/p21 have a close relationship with the occurrence and the malignant development of laryngeal squamous cell carcinoma. Thus, PDCD4 and CDKN1A/p21 could be an indicator of the pathology diagnosis, treatment and prognosis of laryngeal squamous cell carcinoma.
