国际医药卫生导报
國際醫藥衛生導報
국제의약위생도보
INTERNATIONAL MEDICINE & HEALTH GUIDANCE NEWS
2014年
16期
2526-2529
,共4页
氨基葡萄糖%玻璃酸钠%膝关节%骨性关节炎
氨基葡萄糖%玻璃痠鈉%膝關節%骨性關節炎
안기포도당%파리산납%슬관절%골성관절염
Glucosamine hydrochloride%Sodium hyaluronate%Knee%Osteoarthritis
目的 探讨氨基葡萄糖片联合玻璃酸钠注射液治疗膝关节骨性关节炎的临床疗效.方法 选择我院于2012年3月至2013年9月收治的膝关节骨性关节炎的患者142例,随机分为A、B、C三组,其中A组患者采用玻璃酸钠注射液治疗,B组采用氨基葡萄糖片治疗,C组患者采用玻璃酸钠注射液联合氨基葡萄糖片治疗,综合比较三组患者临床治疗效果.结果 治疗后A组疼痛改善(1.2±0.4)分、B组改善(1.1±0.3)分、C组改善(1.9±0.7)分,C组联合用药疼痛改善效果明显优于A、B组单独用药(P＜0.05),三组患者在疗效持续时间、疗效起效时间、关节消肿时间以及治疗前后运动功能评分差值比较差异均有统计学意义(P＜0.05).而联合用药的C组患者各项临床指标优于单独用药的患者(P＜0.05).通过综合考察患者肢体活动度、压痛、活动痛、休息痛、肿痛等五个方面,提示三组患者临床治疗效果差异较大(u＞ua,P＜ 0.05),C组治疗效果远优于单独用药的A组及B组(P＜0.05).结论 玻璃酸钠注射液在改善关节肿胀、功能活动以及维持药效等方面效果显著,而氨基葡萄糖对于改善关节疼痛和关节受限等方面有一定效果,联合使用两者能够迅速减缓膝关节骨性关节炎临床症状,效果持久,值得临床推广应用.
目的 探討氨基葡萄糖片聯閤玻璃痠鈉註射液治療膝關節骨性關節炎的臨床療效.方法 選擇我院于2012年3月至2013年9月收治的膝關節骨性關節炎的患者142例,隨機分為A、B、C三組,其中A組患者採用玻璃痠鈉註射液治療,B組採用氨基葡萄糖片治療,C組患者採用玻璃痠鈉註射液聯閤氨基葡萄糖片治療,綜閤比較三組患者臨床治療效果.結果 治療後A組疼痛改善(1.2±0.4)分、B組改善(1.1±0.3)分、C組改善(1.9±0.7)分,C組聯閤用藥疼痛改善效果明顯優于A、B組單獨用藥(P＜0.05),三組患者在療效持續時間、療效起效時間、關節消腫時間以及治療前後運動功能評分差值比較差異均有統計學意義(P＜0.05).而聯閤用藥的C組患者各項臨床指標優于單獨用藥的患者(P＜0.05).通過綜閤攷察患者肢體活動度、壓痛、活動痛、休息痛、腫痛等五箇方麵,提示三組患者臨床治療效果差異較大(u＞ua,P＜ 0.05),C組治療效果遠優于單獨用藥的A組及B組(P＜0.05).結論 玻璃痠鈉註射液在改善關節腫脹、功能活動以及維持藥效等方麵效果顯著,而氨基葡萄糖對于改善關節疼痛和關節受限等方麵有一定效果,聯閤使用兩者能夠迅速減緩膝關節骨性關節炎臨床癥狀,效果持久,值得臨床推廣應用.
목적 탐토안기포도당편연합파리산납주사액치료슬관절골성관절염적림상료효.방법 선택아원우2012년3월지2013년9월수치적슬관절골성관절염적환자142례,수궤분위A、B、C삼조,기중A조환자채용파리산납주사액치료,B조채용안기포도당편치료,C조환자채용파리산납주사액연합안기포도당편치료,종합비교삼조환자림상치료효과.결과 치료후A조동통개선(1.2±0.4)분、B조개선(1.1±0.3)분、C조개선(1.9±0.7)분,C조연합용약동통개선효과명현우우A、B조단독용약(P＜0.05),삼조환자재료효지속시간、료효기효시간、관절소종시간이급치료전후운동공능평분차치비교차이균유통계학의의(P＜0.05).이연합용약적C조환자각항림상지표우우단독용약적환자(P＜0.05).통과종합고찰환자지체활동도、압통、활동통、휴식통、종통등오개방면,제시삼조환자림상치료효과차이교대(u＞ua,P＜ 0.05),C조치료효과원우우단독용약적A조급B조(P＜0.05).결론 파리산납주사액재개선관절종창、공능활동이급유지약효등방면효과현저,이안기포도당대우개선관절동통화관절수한등방면유일정효과,연합사용량자능구신속감완슬관절골성관절염림상증상,효과지구,치득림상추엄응용.
Objective To investigate the clinical effect of glucosamine hydrochloride combined with sodium hyaluronate in the treatment of knee osteoarthritis.Methods 142 cases of knee osteoarthritis in our hospital from March 2012 to September 2013 were randomly divided into group A,group B and group C.Group A was treated with sodium hyaluronate,group B was treated with glucosamine hydrochloride,group C was treated with sodium hyaluronate and glucosamine hydrochloride.The clinical efficacy was compared after treatment.Results Pain relief improvement in group A was (1.2 ± 0.4),(1.1 ± 0.3) in group B,(1.9 ± 0.7) in group C,pain relief in group C was better than that in group A and group B (P ＜ 0.05).Clinical indicators in group C were better that those in group A and group B (P ＜ 0.05).There were statistically significant differences in physical activity,tenderness,pain,rest pain,swelling between three groups,which suggested that the clinical effect of three groups were quite different (u ＞ ua,P ＜ 0.05).Conclusions Sodium hyaluronate injection has significant effect in improving joint swelling,functional activities and maintaining efficacy,while glucosamine hydrochloride has some effect on improving joint pain and joint constrained.The combination of glucosamine hydrochloride and sodium hyaluronate can quickly relieve clinical symptoms of knee osteoarthritis,worthy of clinical application.
