CAJ | 학술논문

肺癌是预后极差的恶性肿瘤之一，已经上升到肿瘤死亡原因的首位，成为严重威胁人类健康的恶性肿瘤。肺癌的早期治疗除了手术、放疗和化疗外，生物治疗已经成为重要的辅助手段。海参多糖具有多种生物活性，它是从海参体内提取的一种糖胺聚糖，具有良好的抗凝血和抗血栓作用。研究显示其具有抗肿瘤活性及细胞免疫调节功能，通过抑制肿瘤新生血管的形成和抗凝血来实现抗肿瘤作用，通过激活T细胞调节机体细胞免疫功能。本文就海参多糖在抗肺癌活性及T细胞免疫功能调节方面的基础研究进展进行综述。
폐암시예후겁차적악성종류지일，이경상승도종류사망원인적수위，성위엄중위협인류건강적악성종류。폐암적조기치료제료수술、방료화화료외，생물치료이경성위중요적보조수단。해삼다당구유다충생물활성，타시종해삼체내제취적일충당알취당，구유량호적항응혈화항혈전작용。연구현시기구유항종류활성급세포면역조절공능，통과억제종류신생혈관적형성화항응혈래실현항종류작용，통과격활T세포조절궤체세포면역공능。본문취해삼다당재항폐암활성급T세포면역공능조절방면적기출연구진전진행종술。
The lung cancer is one of very poor malignant tumors in prognosis. It has reached the top of cause of death and become to threaten the health of human in malignant tumor. The biotherapy has become the important adjunctive therapy method for pulmonary cancer, apart from surgery, chemotherapy and radiotherapy. The polysaccharide which was selectived from sea cucumber has more important biologic activity substance. It has satisfactory effects in anticoagulated blood and anti-thrombosis as biotherapy, and it has the function of cyto-immunity and anti-neoplastic activity. The activity was carried out by inhibiting the form of neovascular of tumor and anti-coagulated blood. It reinforces the cellular immune function by activating T cells. So, we reviewed the progression of grounding research in anti-lung tumor activity and the regulation of T cellular immune function for polysaccharide from sea cucumber.