CAJ | 학술논문

目的：对63例多发性骨髓瘤（MM）患者的血清免疫固定电泳及血清免疫球蛋白M蛋白的测定结果进行回顾性分析，探讨M蛋白检测在MM诊断中的应用。方法对63例[年龄大于或等于50岁居多（55例），50岁以下较少（8例），男性略多于女性（41∶22）]确诊为MM的患者进行免疫固定电泳、血清蛋白电泳和免疫球蛋白定量测定，并对结果进行分析比较。结果 IgG类患者所占比例最高（68.3%，43/63），游离轻链型MM最低（9.5%，6/63）；无论是κ型还是λ型M蛋白，κ/λ值均显著异常。各种免疫学指标检测M蛋白阳性率，血清κ/λ最高（84.1%，53/63），血清免疫球蛋白定量最低（39.7%，25/63）。结论血清免疫球蛋白M蛋白分类及分型可为临床MM的诊断和治疗提供重要依据。
목적：대63례다발성골수류（MM）환자적혈청면역고정전영급혈청면역구단백M단백적측정결과진행회고성분석，탐토M단백검측재MM진단중적응용。방법대63례[년령대우혹등우50세거다（55례），50세이하교소（8례），남성략다우녀성（41∶22）]학진위MM적환자진행면역고정전영、혈청단백전영화면역구단백정량측정，병대결과진행분석비교。결과 IgG류환자소점비례최고（68.3%，43/63），유리경련형MM최저（9.5%，6/63）；무론시κ형환시λ형M단백，κ/λ치균현저이상。각충면역학지표검측M단백양성솔，혈청κ/λ최고（84.1%，53/63），혈청면역구단백정량최저（39.7%，25/63）。결론혈청면역구단백M단백분류급분형가위림상MM적진단화치료제공중요의거。
Objective To retrospectively analyze the detection results of serum immunofixation electrophoresis (IFE) and serum immunoglobulin M of 63 patients with multiple myeloma (MM),and investigate the application of M protein in the diag-nosis of MM. Methods A total of 63 patients diagnosed with MM ,including 50 cases with the age of 55 years or older and 8 cas-es with the age less than 50 years and the proportion of male to female was 41∶22,were selected to conduct IFE,serum protein electrophoresis and quantitative determination of immunoglobulin. The results were analyzed and compared. Results The pa-tients with IgG had the highest proportion accounting for 68.3%(43/63),and the free light chain MM was the lowest accounting for 9.5%(6/63). Whateverκ-type M protein orλ-type M protein,the ratio ofκ/λwas significantly abnormal. The positive rate of M protein was highest by serumκ/λaccounting for 84.1%(53/63),while lowest by serum immunoglobulin quantitative minimum ac-counting for 39.7%(25/63). Conclusion Classifications and types of M protein provide valuable basis for the diagnosis and treatment of MM clinically.