上海医药
上海醫藥
상해의약
SHANGHAI MEDICAL & PHARMACEUTICAL JOURNAL
2014年
10期
20-23,45
,共5页
陈赛蓉%包家林%徐明%叶曼娜%谢轶群
陳賽蓉%包傢林%徐明%葉曼娜%謝軼群
진새용%포가림%서명%협만나%사질군
浸润性乳腺癌%细胞视黄酸结合蛋白%表皮脂肪酸结合蛋白%临床病理特征%病理分型
浸潤性乳腺癌%細胞視黃痠結閤蛋白%錶皮脂肪痠結閤蛋白%臨床病理特徵%病理分型
침윤성유선암%세포시황산결합단백%표피지방산결합단백%림상병리특정%병리분형
invasive breast cancer%retinoic acid-binding protein II%epidermal fatty acid-binding protein%clinical pathological feature%pathological types
目的：探讨细胞视黄酸结合蛋白（cellular retinoic acid-binding proteinⅡ，CRABPⅡ）和表皮脂肪酸结合蛋白（epidermal fatty acid-binding protein，E-FABP）的差异表达在乳腺癌中的意义，以及与临床病理特征和分型的关系。方法：分析123例浸润性乳腺癌患者的临床资料，采用免疫组化法检测乳腺癌组织中CRABPⅡ和E-FABP的表达。结果：CRABPⅡ和E-FABP在浸润性乳腺癌的表达存在显著差异（P<0.01）。此差异表达分为E-FABP≥CRABPⅡ与E-FABP﹤CRABPⅡ两种。在浸润性乳腺癌中，E-FABP≥CRABPⅡ的表达较多见。CRABPⅡ和E-FABP的差异表达与腋窝淋巴结转移和TNM分期有关(P<0.05)。差异表达与病理分型相关，Luminal A型中E-FABP≥CRABPⅡ的百分率最低(61.6%)，Basal-like型中的百分率最高(95.2%)。结论：在浸润性乳腺癌中，CRABPⅡ和E-FABP的差异表达可能与乳腺癌的侵袭性及预后相关，E-FABP≥CRABPⅡ时的乳腺癌侵袭性高、预后差。
目的：探討細胞視黃痠結閤蛋白（cellular retinoic acid-binding proteinⅡ，CRABPⅡ）和錶皮脂肪痠結閤蛋白（epidermal fatty acid-binding protein，E-FABP）的差異錶達在乳腺癌中的意義，以及與臨床病理特徵和分型的關繫。方法：分析123例浸潤性乳腺癌患者的臨床資料，採用免疫組化法檢測乳腺癌組織中CRABPⅡ和E-FABP的錶達。結果：CRABPⅡ和E-FABP在浸潤性乳腺癌的錶達存在顯著差異（P<0.01）。此差異錶達分為E-FABP≥CRABPⅡ與E-FABP﹤CRABPⅡ兩種。在浸潤性乳腺癌中，E-FABP≥CRABPⅡ的錶達較多見。CRABPⅡ和E-FABP的差異錶達與腋窩淋巴結轉移和TNM分期有關(P<0.05)。差異錶達與病理分型相關，Luminal A型中E-FABP≥CRABPⅡ的百分率最低(61.6%)，Basal-like型中的百分率最高(95.2%)。結論：在浸潤性乳腺癌中，CRABPⅡ和E-FABP的差異錶達可能與乳腺癌的侵襲性及預後相關，E-FABP≥CRABPⅡ時的乳腺癌侵襲性高、預後差。
목적：탐토세포시황산결합단백（cellular retinoic acid-binding proteinⅡ，CRABPⅡ）화표피지방산결합단백（epidermal fatty acid-binding protein，E-FABP）적차이표체재유선암중적의의，이급여림상병리특정화분형적관계。방법：분석123례침윤성유선암환자적림상자료，채용면역조화법검측유선암조직중CRABPⅡ화E-FABP적표체。결과：CRABPⅡ화E-FABP재침윤성유선암적표체존재현저차이（P<0.01）。차차이표체분위E-FABP≥CRABPⅡ여E-FABP﹤CRABPⅡ량충。재침윤성유선암중，E-FABP≥CRABPⅡ적표체교다견。CRABPⅡ화E-FABP적차이표체여액와림파결전이화TNM분기유관(P<0.05)。차이표체여병리분형상관，Luminal A형중E-FABP≥CRABPⅡ적백분솔최저(61.6%)，Basal-like형중적백분솔최고(95.2%)。결론：재침윤성유선암중，CRABPⅡ화E-FABP적차이표체가능여유선암적침습성급예후상관，E-FABP≥CRABPⅡ시적유선암침습성고、예후차。
Objective:To explore the signiifcance of the different expressions of cellular retinoic acid-binding proteinⅡ(CRABP Ⅱ ) and epidermal fatty acid-binding protein (E-FABP) in the breast cancer and the relationship of their clinical pathological features and types. Methods: The clinical data on 123 cases with invasive breast cancer were analyzed and the expressions of CRABP Ⅱand E-FABP were detected by immunohistochemistry in the breast cancer tissues. Results:There existed different expressions between CRAB Ⅱand E-FABP in the invasive breast cancer (P<0.01), which could be classiifed into two types of E-FABP≥CRABP Ⅱand E-FABP<CRABPⅡ. The expression of E-FABP≥CRABP II was seen more in the invasive breast cancer. The different expressions of CRABP II and E-FABP were related to axillary lymph node metastasis and TNM staging. Different expression was related to pathological types. The percentage rate of E-FABP≥CRABPⅡwas the lowest in Luminal A subtype (61.1%) and the highest (95.2%) in Basal-like type. Conclusions:In the invasive breast cancer the different expressions of CRABP Ⅱand E-FABP may have the relationship with the invasion and prognosis of the breast cancer. When E-FABP is ≥CRABPⅡ, the breast cancer has higher invasion and its prognosis is poor.
