CAJ | 학술논문

目的：探讨脑钠肽（BNP）和 N末端B型利钠肽前体（NT-proBNP）对急性呼吸窘迫综合征患者诊断中的意义以及对治疗的指导作用。方法：对124例有明确器质性心脏病或者突发呼吸窘迫患者（检测组）进行 BNP和NT-proBNP检查，判断心衰与否。另选110例发生急性呼吸窘迫但未做BNP、NT-proBNP检查的患者作为未检测对照组，收集所有患者诊断时间、住院时间、住院费用、死亡率等相关资料。结果：与未检测对照组比较，检测组诊断时间[（24.2±6.4）min比（16.3±5.2）min]、住院时间显著缩短[（12.5±3.5）d比（8.5±4.5）d]，死亡率显著降低（8.18％比4.84％），P均＜0.05；两组平均住院费用无明显差异（P＞0.05）。结论：脑钠肽和N末端B型利钠肽前体的检测对于早期诊断急性呼吸窘迫综合征，提高疗效和改善预后有重要价值。
목적：탐토뇌납태（BNP）화 N말단B형리납태전체（NT-proBNP）대급성호흡군박종합정환자진단중적의의이급대치료적지도작용。방법：대124례유명학기질성심장병혹자돌발호흡군박환자（검측조）진행 BNP화NT-proBNP검사，판단심쇠여부。령선110례발생급성호흡군박단미주BNP、NT-proBNP검사적환자작위미검측대조조，수집소유환자진단시간、주원시간、주원비용、사망솔등상관자료。결과：여미검측대조조비교，검측조진단시간[（24.2±6.4）min비（16.3±5.2）min]、주원시간현저축단[（12.5±3.5）d비（8.5±4.5）d]，사망솔현저강저（8.18％비4.84％），P균＜0.05；량조평균주원비용무명현차이（P＞0.05）。결론：뇌납태화N말단B형리납태전체적검측대우조기진단급성호흡군박종합정，제고료효화개선예후유중요개치。
Objective:To explore significance of brain natriuretic peptide (BNP)and N terminal pro brain natriuretic peptide (NT-proBNP)for diagnosis of acute respiratory distress syndrome and its guidance of treatment.Methods:A total of 124 cases with definite organic heart disease and sudden respiratory distress syndrome (measurement group) received measurement of BNP and NT-proBNP to judge whether they suffered from heart failure or not.Another 110 patients with acute respiratory distress syndrome but no receiving BNP and NT-proBNP measurement were en-rolled as no measurement control group.Relevant data,including diagnosis time,length of hospital stay,hospitali-zation cost and mortality rate etc,were collected in all patients.Results:Compared with no measurement control group,there were significant reductions in diagnosis time [(24.2±6.4)min vs.(16.3±5.2)min],length of hospi-tal stay [(12.5±3.5)d vs.(8.5±4.5)d]and mortality rate (8.18% vs.4.84%)in measurement group,P<0.05 all;there was no significant difference in mean hospitalization cost between two groups (P>0.05).Conclusion:Measurement of brain natriuretic peptide and N terminal pro brain natriuretic peptide possesses important value for early diagnosis,elevating therapeutic effect and improving prognosis in patients with acute respiratory distress syn-drome.