心血管康复医学杂志
心血管康複醫學雜誌
심혈관강복의학잡지
JOURNAL OF CARDIOVASCULAR REHABILITATION MEDICINE
2014年
3期
268-270
,共3页
肾上腺髓质%C反应蛋白质%冠状动脉疾病
腎上腺髓質%C反應蛋白質%冠狀動脈疾病
신상선수질%C반응단백질%관상동맥질병
Adrenal medulla%C reactive protein%Coronary artery disease
目的：探讨在急性冠脉综合征（ACS）患者测定肾上腺髓质素（ADM）和超敏 C-反应蛋白（hsCRP）的意义。方法：选择51例经冠脉造影排除冠心病的住院患者（非冠心病组）和124例经冠脉造影确诊为 ACS的患者（ACS组）。测定非冠心病组冠脉造影前后及 ACS组冠脉介入治疗前后 ADM和 hsCRP 的浓度，并进行统计学比较。结果：在造影/介入治疗前，与非冠心病组比较，ACS组 ADM [（28.7±1.6）pg/ml比（36.7±2.5）pg/ml]和 hsCRP [（4.74±3.21）mg/L比（27.65±11.76）mg/L]水平明显升高（P＜0.05或＜0.01）。与冠脉介入前比较，ACS组在冠脉介入后 ADM [（36.7±2.5）pg/ml比（47.1±5.3）pg/ml]和 hsCRP [（27.65±11.76）mg/L比（39.53±4.83）mg/L]水平显著上升（P均＜0.01），且显著高于非冠心病组（P＜0.05～＜0.01）。非冠心病组在冠脉造影前后 ADM和 hsCRP水平无统计学差异（P均＞0.05）。结论：测定肾上腺髓质素联合超敏 C-反应蛋白水平有助于急性冠脉综合征早期诊断及其病变严重程度判断。
目的：探討在急性冠脈綜閤徵（ACS）患者測定腎上腺髓質素（ADM）和超敏 C-反應蛋白（hsCRP）的意義。方法：選擇51例經冠脈造影排除冠心病的住院患者（非冠心病組）和124例經冠脈造影確診為 ACS的患者（ACS組）。測定非冠心病組冠脈造影前後及 ACS組冠脈介入治療前後 ADM和 hsCRP 的濃度，併進行統計學比較。結果：在造影/介入治療前，與非冠心病組比較，ACS組 ADM [（28.7±1.6）pg/ml比（36.7±2.5）pg/ml]和 hsCRP [（4.74±3.21）mg/L比（27.65±11.76）mg/L]水平明顯升高（P＜0.05或＜0.01）。與冠脈介入前比較，ACS組在冠脈介入後 ADM [（36.7±2.5）pg/ml比（47.1±5.3）pg/ml]和 hsCRP [（27.65±11.76）mg/L比（39.53±4.83）mg/L]水平顯著上升（P均＜0.01），且顯著高于非冠心病組（P＜0.05～＜0.01）。非冠心病組在冠脈造影前後 ADM和 hsCRP水平無統計學差異（P均＞0.05）。結論：測定腎上腺髓質素聯閤超敏 C-反應蛋白水平有助于急性冠脈綜閤徵早期診斷及其病變嚴重程度判斷。
목적：탐토재급성관맥종합정（ACS）환자측정신상선수질소（ADM）화초민 C-반응단백（hsCRP）적의의。방법：선택51례경관맥조영배제관심병적주원환자（비관심병조）화124례경관맥조영학진위 ACS적환자（ACS조）。측정비관심병조관맥조영전후급 ACS조관맥개입치료전후 ADM화 hsCRP 적농도，병진행통계학비교。결과：재조영/개입치료전，여비관심병조비교，ACS조 ADM [（28.7±1.6）pg/ml비（36.7±2.5）pg/ml]화 hsCRP [（4.74±3.21）mg/L비（27.65±11.76）mg/L]수평명현승고（P＜0.05혹＜0.01）。여관맥개입전비교，ACS조재관맥개입후 ADM [（36.7±2.5）pg/ml비（47.1±5.3）pg/ml]화 hsCRP [（27.65±11.76）mg/L비（39.53±4.83）mg/L]수평현저상승（P균＜0.01），차현저고우비관심병조（P＜0.05～＜0.01）。비관심병조재관맥조영전후 ADM화 hsCRP수평무통계학차이（P균＞0.05）。결론：측정신상선수질소연합초민 C-반응단백수평유조우급성관맥종합정조기진단급기병변엄중정도판단。
Objective:To explore the clinical significance detecting adrenomedullin (ADM)and high sensitive C reac-tive protein (hsCRP)in patients with acute coronary syndrome (ACS).Methods:A total of 51 inpatients,which were eliminated for coronary heart disease (CHD)by coronary angiography (CAG),were enrolled as non CHD group,and 124 ACS patients diagnosed by CAG were regarded as ACS group.ADM and hsCRP concentrations were measured before and after CAG in non CHD group and before and after percutaneous coronary intervention (PCI) in ACS group,and they were compared between two groups.Results:Before CAG/PCI,compared with non CHD group,ADM [(28.7±1.6)pg/ml vs.(36.7±2.5)pg/ml]and hsCRP [(4.74±3.21)mg/L vs.(27.65±11.76) mg/L]levels significantly rose in ACS group,P<0.05 or <0.01.Compared with before PCI,there were signifi-cant increase in levels of ADM [(36.7±2.5)pg/ml vs.(47.1±5.3)pg/ml]and hsCRP [(27.65±11.76)mg/L vs.(39.53±4.83)mg/L]in ACS group after PCI,P<0.01 both,and significantly higher than those of non CHD group (P<0.05~<0.01).There were no significant difference in ADM and hsCRP levels in non CHD group be-tween before and after CAG (P>0.05 all).Conclusion:Detecting arenomedullin combined high sensitive C-reac-tive protein is gelpful to early diagnosis and evaluating lesion severity for acute coronary syndrome.
