CAJ | 학술논문

目的：评价医用水凝胶作为冷敷材料在激光治疗术中及术后的临床疗效和安全性。方法国内6家医疗单位随机选取100例患者，其中行强脉冲光治疗52例，激光脱毛治疗26例，色素性疾病22例。采用自身对照，一侧面部（一侧肢体）使用水凝胶，另外一侧作为空白对照。在激光脱毛治疗前将水凝胶贴敷于激光治疗部位，直接透过水凝胶做激光穿透治疗，强脉冲光治疗时用水凝胶替代普通凝胶，其他激光术后将水凝胶贴敷于激光治疗部位。分别于术中、术后30 min和术后7 d观察并评价症状和体征，以及不良反应发生率。结果治疗术中、术后30 min 患者和医师评价红斑、灼热、肿胀评分明显降低，水凝胶侧优于对照侧（P ＜0.05）；治疗后30 min 临床症状消退评分水凝胶侧明显优于对照侧（P ＜0.05）；术后7 d 患者和医师体征评分和临床症状消退评分水凝胶侧与对照侧无差异（P ＞0.05）；无1例患者出现不良反应。结论医用水凝胶在激光治疗中和术后短期内可以有效改善患者不适感和降低激光术后皮肤反应，提高患者依从性和舒适度。
목적：평개의용수응효작위랭부재료재격광치료술중급술후적림상료효화안전성。방법국내6가의료단위수궤선취100례환자，기중행강맥충광치료52례，격광탈모치료26례，색소성질병22례。채용자신대조，일측면부（일측지체）사용수응효，령외일측작위공백대조。재격광탈모치료전장수응효첩부우격광치료부위，직접투과수응효주격광천투치료，강맥충광치료시용수응효체대보통응효，기타격광술후장수응효첩부우격광치료부위。분별우술중、술후30 min화술후7 d관찰병평개증상화체정，이급불량반응발생솔。결과치료술중、술후30 min 환자화의사평개홍반、작열、종창평분명현강저，수응효측우우대조측（P ＜0.05）；치료후30 min 림상증상소퇴평분수응효측명현우우대조측（P ＜0.05）；술후7 d 환자화의사체정평분화림상증상소퇴평분수응효측여대조측무차이（P ＞0.05）；무1례환자출현불량반응。결론의용수응효재격광치료중화술후단기내가이유효개선환자불괄감화강저격광술후피부반응，제고환자의종성화서괄도。
ObjectiveTo evaluate the safety, efficacy, and patient acceptance of hydrogel dressings applied in laser dermatology. MethodsOne hundred patients underwent laser dermatology were selected randomly over 6 hospitals in China. The hydrogel dressing was applied to their corresponding treatment skin as cooling material, which laser directly went through. Intense pulsed light therapy in 52 cases, laser hair removal in 26 cases and 22 cases of pigmented diseases were selected. Using self control, half face (side limb) using hydrogel, the other half as blank control. In a hydrogel coated on the laser treatment in site would before treatment, laser hair removal, directly through the hydrogel treatment laser, intense pulsed light in the treatment of water gel instead of conventional gel, other laser surgery would be pasted on the laser treatment in site hydrogel. Respectively during the operation, after 30 minutes and 7 days after operation to observe and evaluate the patient and physician assessment of the incidence of clinical symptoms and signs, doctor VAS score and adverse reactions.ResultsThere were signiifcant difference in the operative& postoperative criteria of bruises, pain, erythema and swelling between the side of the hydrogel and the control side (P<0.05). The score of clinical symptoms after 30 minutes in hydrogel side was better than the control side after treatment (P<0.05). There were no signiifcant difference after 7 days between two sides (P>0.05). And there were no complications of surface irregularities or contact dermatitis from the application or maintenance of hydrogel dressings.ConclusionsHydrogel dressings are safe and effective to reduce side effects of laser dermatology and patients are compliant with overall acceptance.