CAJ | 학술논문

目的：探讨垂体生长激素腺瘤病人经蝶窦显微术后IGF-I水平与高血压、糖尿病等并发症的关系。方法回顾性调查经蝶窦手术治疗资料完整的73例垂体生长激素腺瘤患者的临床资料，其中伴有糖尿病21例，高血压15例，按术后IGF-I水平治愈标准评价手术疗效，分析IGF-I水平与高血压、糖尿病的关系。结果15例IGF-I水平正常者中有11例糖尿病症状缓解，6例IGF-I水平未恢复正常者中有1例糖尿病症状缓解（P＜0．05）；10例IGF-I水平正常者中有6例高血压症状缓解，5例IGF-I水平未恢复正常者中有1例高血压症状缓解。结论垂体生长激素腺瘤术后IGF-I水平恢复正常，能改善肢端肥大症病人糖尿病、高血压的临床症状。
목적：탐토수체생장격소선류병인경접두현미술후IGF-I수평여고혈압、당뇨병등병발증적관계。방법회고성조사경접두수술치료자료완정적73례수체생장격소선류환자적림상자료，기중반유당뇨병21례，고혈압15례，안술후IGF-I수평치유표준평개수술료효，분석IGF-I수평여고혈압、당뇨병적관계。결과15례IGF-I수평정상자중유11례당뇨병증상완해，6례IGF-I수평미회복정상자중유1례당뇨병증상완해（P＜0．05）；10례IGF-I수평정상자중유6례고혈압증상완해，5례IGF-I수평미회복정상자중유1례고혈압증상완해。결론수체생장격소선류술후IGF-I수평회복정상，능개선지단비대증병인당뇨병、고혈압적림상증상。
Objective To evaluate the relationship of postoperative Insulin-like growth factor I (IGF-I).level with diabetes and hypertensions for growth hormone (GH)-secreting adenoma patients after transsphenoidal microsurgery. Methods Seventy-three patients harboring GH-secreting adenomas underwent transsphenoidal microsurgery were investigated retrospectively. .Biochemical remission was defined as a normal age- and gender-matched IGF-I level. Among them , 21 cases were diabetes and 15 cases were hypertensions..Results Eleven cases got clinical symptomatic relief in diabetes among 15 cases with normal IGF-I level,and one case was clinical symptomatic relief among 6 cases with abnormal IGF-I level (P<0.05)..Six cases were hypertension clinical symptomatic relief among 10 cases with normal IGF-I level,.and one case was hypertension clinical symptomatic relief among 5 cases with abnormal IGF-I level..Conclusion Normal postoperative IGF-I level could moderate diabetes and hyperten-sion clinical symptoms for acromegalic patients with GH-secreting adenomas.