CAJ | 학술논문

目的：通过对肝癌患者术前血清球蛋白/胆碱脂酶比值与child-pugh评分的对比性分析，探讨肝癌术前更简单、更可靠的反映肝脏储备功能和对术后肝功能不全发生率更具敏感性、特异性的方法。方法回顾性分析中山大学孙逸仙纪念医院从2012年5月至2014年1行肝癌切除患者共174例，其中男性138例，女性36例，分析患者术前血清球蛋白/胆碱脂酶比值（G/C），与child-pugh分级中A、B、C三级病例进行对比分析。结果球蛋白/胆碱脂酶比值与child-pugh评分在术前肝功能评估中均呈正相关（r＝0．307；P＜0．05）。血清球蛋白/胆碱脂酶比值（OR＝4．668，P＝0．04）在预测术后肝功能不全发生机率优于Child-Pugh分级（OR＝2．909， P＝0．126）。结论肝癌患者术前血清球蛋白/胆碱脂酶比值评估术前肝储备功能与child-pugh分级呈正相关，但在预测术后肝功能不全发生机率优于child-pugh分级。
목적：통과대간암환자술전혈청구단백/담감지매비치여child-pugh평분적대비성분석，탐토간암술전경간단、경가고적반영간장저비공능화대술후간공능불전발생솔경구민감성、특이성적방법。방법회고성분석중산대학손일선기념의원종2012년5월지2014년1행간암절제환자공174례，기중남성138례，녀성36례，분석환자술전혈청구단백/담감지매비치（G/C），여child-pugh분급중A、B、C삼급병례진행대비분석。결과구단백/담감지매비치여child-pugh평분재술전간공능평고중균정정상관（r＝0．307；P＜0．05）。혈청구단백/담감지매비치（OR＝4．668，P＝0．04）재예측술후간공능불전발생궤솔우우Child-Pugh분급（OR＝2．909， P＝0．126）。결론간암환자술전혈청구단백/담감지매비치평고술전간저비공능여child-pugh분급정정상관，단재예측술후간공능불전발생궤솔우우child-pugh분급。
Objective To investigate a method for predicting sensitively and specifically hepatic insufficiency by comparing globulin/cholinesterase (G/C) ratio with Child-Pugh scores in advance of hepatec-tomy in liver cancer patients. Methods We recruited patients retrospectively from May 2012 to January 2014 undergoing HCC hepatectomy in Sun Yat-Sen University Memorial Hospital,.including 138 males and 36 females. The study was conducted by analysis of G/C ratio compared with A,.B and C levels of Child-Pugh classification respectively. Results G/C ratio had positive relationship with Child-Pugh classification in evaluating preo-perative liver function(r=0.307, P<0.05). G/C ratio (OR=4.668, P=0.04) preceded Child-Pugh classification (OR=2.909, P=0.126) in predicting incidence of postoperative hepatic insufficiency. Conclusion In our present study , G/C ratio had positive correlation with Child-Pugh classification in evaluating liver reserve function preoperatively in HCC patients , but the former was superior to Child-Pugh classification in predicting hepatic insufficiency postoperatively.