中国综合临床
中國綜閤臨床
중국종합림상
CLINICAL MEDICINE OF CHINA
2014年
9期
953-956
,共4页
梁育飞%郑国启%李春英%孙宁宁%杨雨鑫
樑育飛%鄭國啟%李春英%孫寧寧%楊雨鑫
량육비%정국계%리춘영%손저저%양우흠
局限型腹膜间皮瘤%石棉%外科手术
跼限型腹膜間皮瘤%石棉%外科手術
국한형복막간피류%석면%외과수술
Localized peritoneal mesothelioma%Asbestos%Operation surgury
目的 探讨局限型恶性腹膜间皮瘤的临床特点及其发病与石棉接触的关系.方法 收集2007年1月1日至2012年12月31日我院诊治的经病理学确诊的局限型恶性腹膜间皮瘤22例患者的临床资料,对其发病情况、石棉接触史、临床表现、影像学检查、病理类型、免疫组织化学及肿瘤标记物检查结果等进行分析.结果 22例中多见于女性,占68.18％.出现症状至就诊时间为2d～1年,平均83 d.临床症状中局部腹痛者11例(50.00％)、腹部包块者8例(36.36％)、腹胀者6例(27.27％)、腹水者10例(45.45％).患者多具有血小板数量增多、癌抗原(CA) 125升高.腹部CT检查表现为局部肿块,多呈囊实性,12例可见石棉斑(54.55％).腹部超声及腹部CT检查是主要的检查方法,超声引导下腹膜穿刺病理活检是确诊的主要手段,其次为剖腹探查.病理类型主要多为上皮型共19例(86.36％),其次为肉瘤型和混合型.18例患者(81.82％)有石棉接触史.结论 局限型恶性腹膜间皮瘤在我国少见,但在本地区较为多见,可能与石棉接触有关;临床特征以腹痛和局部肿块表现为主;病理类型以上皮型为主;手术是其主要的治疗方式.
目的 探討跼限型噁性腹膜間皮瘤的臨床特點及其髮病與石棉接觸的關繫.方法 收集2007年1月1日至2012年12月31日我院診治的經病理學確診的跼限型噁性腹膜間皮瘤22例患者的臨床資料,對其髮病情況、石棉接觸史、臨床錶現、影像學檢查、病理類型、免疫組織化學及腫瘤標記物檢查結果等進行分析.結果 22例中多見于女性,佔68.18％.齣現癥狀至就診時間為2d～1年,平均83 d.臨床癥狀中跼部腹痛者11例(50.00％)、腹部包塊者8例(36.36％)、腹脹者6例(27.27％)、腹水者10例(45.45％).患者多具有血小闆數量增多、癌抗原(CA) 125升高.腹部CT檢查錶現為跼部腫塊,多呈囊實性,12例可見石棉斑(54.55％).腹部超聲及腹部CT檢查是主要的檢查方法,超聲引導下腹膜穿刺病理活檢是確診的主要手段,其次為剖腹探查.病理類型主要多為上皮型共19例(86.36％),其次為肉瘤型和混閤型.18例患者(81.82％)有石棉接觸史.結論 跼限型噁性腹膜間皮瘤在我國少見,但在本地區較為多見,可能與石棉接觸有關;臨床特徵以腹痛和跼部腫塊錶現為主;病理類型以上皮型為主;手術是其主要的治療方式.
목적 탐토국한형악성복막간피류적림상특점급기발병여석면접촉적관계.방법 수집2007년1월1일지2012년12월31일아원진치적경병이학학진적국한형악성복막간피류22례환자적림상자료,대기발병정황、석면접촉사、림상표현、영상학검사、병리류형、면역조직화학급종류표기물검사결과등진행분석.결과 22례중다견우녀성,점68.18％.출현증상지취진시간위2d～1년,평균83 d.림상증상중국부복통자11례(50.00％)、복부포괴자8례(36.36％)、복창자6례(27.27％)、복수자10례(45.45％).환자다구유혈소판수량증다、암항원(CA) 125승고.복부CT검사표현위국부종괴,다정낭실성,12례가견석면반(54.55％).복부초성급복부CT검사시주요적검사방법,초성인도하복막천자병리활검시학진적주요수단,기차위부복탐사.병리류형주요다위상피형공19례(86.36％),기차위육류형화혼합형.18례환자(81.82％)유석면접촉사.결론 국한형악성복막간피류재아국소견,단재본지구교위다견,가능여석면접촉유관;림상특정이복통화국부종괴표현위주;병리류형이상피형위주;수술시기주요적치료방식.
Objective To explore the clinical characteristics of localized peritoneal mesothelioma by the retrospective analysis of the clinical data and its relationship with asbestos exposure.Methods A total of 22 cases with localized peritoneal mesothelioma confirmed by pathological test and they were selected as our subjects in the Central Hospital of Cangzhou from Jan.2007 to Dec.2012.The information of all cases was collected.The incidence,asbestos exposure history,clinical manifestations,imaging studies,pathological type,immunohistochemistry and tumor markers of peritoneal mesotheliom patients were recorded or measured.Results Of 22 cases,female accounted for 68.18％.The periods from onset symptoms to treatment time was from 2 days to 1 year with an average of 83 days.Clinical symptoms were verified including localized abdominal pain (11 cases,50.00％),abdominal mass (8 cases,36.36％),abdominal distension (6 cases,27.27％),ascites (10 cases,45.45％).Patient was with increased platelet and carcinoma antigen 125.Abdominal computerized tomography showed that local mass was seen and 12 cases were with asbestos spot.Ultrasound-guided peritoneal biopsy was confirmed as the main diagnostic method followed by Laparotomy.Epithelial type was the main pathological type (19 cases,86.36％),following the fleshy tumor type and mixed type.Eighteen cases had asbestos exposure history.Conclusion Localized peritoneal mesothelioma is a rare disease.However,the incidence is high in the current region due to asbestos exposure.Abdominal pain and local mass are the main clinical symptoms,and the main pathology is epithelial typeas well as surgery is the main therapy.
