井冈山大学学报（自然科学版）
井岡山大學學報（自然科學版）
정강산대학학보（자연과학판）
JOURNAL OF JINGGANGSHAN UNIVERSITY(SCIENCE AND TECHNOLOGY)
2014年
3期
35-37,49
,共4页
2-1-(2-吡啶)乙氧基乙酸乙酯%合成%学习记忆%小鼠
2-1-(2-吡啶)乙氧基乙痠乙酯%閤成%學習記憶%小鼠
2-1-(2-필정)을양기을산을지%합성%학습기억%소서
ethyl 2- [1-(pyridin-2-yl)ethoxy]acetate%synthesis%learning and memory%mice
为探讨2-[1-(2-吡啶)乙氧基]乙酸2-取代胺基乙酯衍生物对小鼠学习记忆能力的影响，使用2-乙基吡啶为起始原料，经Whol-ziegler反应得到2-(1-溴乙基)吡啶(2),再与羟基乙酸乙酯的醇钠盐缩合得到2-[1-(2-吡啶)乙氧基]乙酸乙酯(3),化合物3与2-取代胺基乙醇在二丁基氧化锡催化下反应，得到目标产物2-[1-(2-吡啶)乙氧基]乙酸-2-取代胺基乙酯(4~12)。采用通道式水迷宫法测定了化合物(5,6,10)对小鼠学习记忆能力的影响。结果显示化合物6和10对400 mL/L乙醇所致小鼠学习记忆再现困难具有明显改善作用(P＜0.05)。
為探討2-[1-(2-吡啶)乙氧基]乙痠2-取代胺基乙酯衍生物對小鼠學習記憶能力的影響，使用2-乙基吡啶為起始原料，經Whol-ziegler反應得到2-(1-溴乙基)吡啶(2),再與羥基乙痠乙酯的醇鈉鹽縮閤得到2-[1-(2-吡啶)乙氧基]乙痠乙酯(3),化閤物3與2-取代胺基乙醇在二丁基氧化錫催化下反應，得到目標產物2-[1-(2-吡啶)乙氧基]乙痠-2-取代胺基乙酯(4~12)。採用通道式水迷宮法測定瞭化閤物(5,6,10)對小鼠學習記憶能力的影響。結果顯示化閤物6和10對400 mL/L乙醇所緻小鼠學習記憶再現睏難具有明顯改善作用(P＜0.05)。
위탐토2-[1-(2-필정)을양기]을산2-취대알기을지연생물대소서학습기억능력적영향，사용2-을기필정위기시원료，경Whol-ziegler반응득도2-(1-추을기)필정(2),재여간기을산을지적순납염축합득도2-[1-(2-필정)을양기]을산을지(3),화합물3여2-취대알기을순재이정기양화석최화하반응，득도목표산물2-[1-(2-필정)을양기]을산-2-취대알기을지(4~12)。채용통도식수미궁법측정료화합물(5,6,10)대소서학습기억능력적영향。결과현시화합물6화10대400 mL/L을순소치소서학습기억재현곤난구유명현개선작용(P＜0.05)。
To discuss the effects of 2-substituted aminoethyl 2-[ (1-(pyridin-2-yl)ethoxy)] acetates on learning and memory facilitation in mice, 2-(1-bromorthyl)pynidine (2) was synthesized through Whol-ziegler reaction using 2-ethylpyridine as the starting material, which further reacted with 2-ethoxy-2-oxo-ethanolate to give ethyl 2-[1-(pyridine-2-yl)ethoxy] acetate (3).The target compounds 2-substituted aminoethyl 2-[ (1-(pyridin-2-yl)ethoxy)] acetates (4-12) were prepared by reacting compound3 with 2-substituted aminoethyl using dibutyl tinoxide as a catalyst. The effects of compounds5, 6, and 10on memory disorder induced by alcohol in mice were studied by swimming maze test. The pharmacological results showed that the compounds6 and 10could improve the ability of learning and memory in mice.
