哈尔滨商业大学学报（自然科学版）
哈爾濱商業大學學報（自然科學版）
합이빈상업대학학보（자연과학판）
JOURNAL OF HARBIN UNIVERSITY OF COMMERCE(NATURAL SCIENCES EDITION)
2014年
3期
264-265,274
,共3页
张亮%管庆霞%赵义军%高佳翔%李永吉
張亮%管慶霞%趙義軍%高佳翔%李永吉
장량%관경하%조의군%고가상%리영길
马钱子碱%固体脂质纳米粒%包封率%葡聚糖凝胶法
馬錢子堿%固體脂質納米粒%包封率%葡聚糖凝膠法
마전자감%고체지질납미립%포봉솔%포취당응효법
brucine%solid lipid nanoparticles%encapsulating efficiency%sephadex gel
建立马钱子碱固体脂质纳米粒中药物包封率的测定方法．采用葡聚糖凝胶柱层析法分离马钱子碱固体脂质纳米粒胶体溶液，再用HPLC测定溶液中马钱子碱的质量浓度，计算包封率．该法测定马钱子碱固体脂质纳米粒中马钱子碱的平均包封率为68．13％，RSD值为0．59％．葡聚糖凝胶法简便，准确，可以作为马钱子碱固体脂质纳米粒的包封率测定方法．
建立馬錢子堿固體脂質納米粒中藥物包封率的測定方法．採用葡聚糖凝膠柱層析法分離馬錢子堿固體脂質納米粒膠體溶液，再用HPLC測定溶液中馬錢子堿的質量濃度，計算包封率．該法測定馬錢子堿固體脂質納米粒中馬錢子堿的平均包封率為68．13％，RSD值為0．59％．葡聚糖凝膠法簡便，準確，可以作為馬錢子堿固體脂質納米粒的包封率測定方法．
건립마전자감고체지질납미립중약물포봉솔적측정방법．채용포취당응효주층석법분리마전자감고체지질납미립효체용액，재용HPLC측정용액중마전자감적질량농도，계산포봉솔．해법측정마전자감고체지질납미립중마전자감적평균포봉솔위68．13％，RSD치위0．59％．포취당응효법간편，준학，가이작위마전자감고체지질납미립적포봉솔측정방법．
In order to establish a method for determining the entrapment efficiency of brucine solid lipid nanoparticles Sephadex gel were used to separate free brucine from solid lipid nan -oparticles,the concentration of brucine was determined by HPLC .Determination of the aver-age entrapment efficiency of Sephadex gel was 68.13%, RSD values were 0.59%.This method was convenient , accurate , and can be used to determine the entrapment efficiency of brucine solid lipid nanoparticles .
