CAJ | 학술논문

研究马钱子碱固体脂质纳米粒的药动学特点．以马钱子碱为对照，在设计的时间点大鼠眼眶取血，采用RP-HPLC测定马钱子碱在全血中的药物质量浓度，药动学参数用3 P97软件进行处理，拟合药动学参数．结果马钱子及其固体脂质纳米粒的均符合权重为1的二室模型，纳米粒组与原药组相比，T1/2β从50．20 min延长至136．23 min，AUC由417．32（μg/mL）/min增至2336．03（μg/mL）/min．马钱子碱固体脂质纳米粒在大鼠体内的消除半衰期显著延长，生物利用度显著提高，延长了药物在体内的存留时间，呈现长效作用．
연구마전자감고체지질납미립적약동학특점．이마전자감위대조，재설계적시간점대서안광취혈，채용RP-HPLC측정마전자감재전혈중적약물질량농도，약동학삼수용3 P97연건진행처리，의합약동학삼수．결과마전자급기고체지질납미립적균부합권중위1적이실모형，납미립조여원약조상비，T1/2β종50．20 min연장지136．23 min，AUC유417．32（μg/mL）/min증지2336．03（μg/mL）/min．마전자감고체지질납미립재대서체내적소제반쇠기현저연장，생물이용도현저제고，연장료약물재체내적존류시간，정현장효작용．
The pharmacokinetic characteristics of brucine solid lipid nanoparticles were stud-ied in this paper .Taking the brucine as control , at the design time point , orbital blood was taken.Then the brucine concentration in the whole blood was determined by RP -HPLC, and the data was processed by 3 P97 software to fit the pharmacokinetic parameters .Pharma-cokinetic results showed that drug and time processes of brucine and brucine solid lipid nano -particles were in accordance with dynamic characteristics of linear two-compartment model . Compared with group brucine , T1/2βin group brucine solid lipid nanoparticles extended from 61.91 min to 172.11 min, AUC was significantly increased from 610.74 (μg/mL)/min to 3 024.34 (μg/mL)/min.The elimination half-life of brucine solid lipid nanoparticles freeze-dried powder in mouse was significantly longer .The bioavailability was improved sig-nificantly .The lifetime of drug in vivo was extended , which presented long-lasting effect .